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Article
Open AccessGenome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma
Multiple myeloma (MM) and its precursors monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) are 2–3 times more common in African Americans (AA) than European Americans (EA)....
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Article
Open AccessCell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia
Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic feature in many cancers including acute myeloid leukemia (AML). However, genome-wide analysis of 5hmC in plasma cell-free DNA (cfDNA) ...
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Article
Open AccessA human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development an...
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Article
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation
Copper is a transition metal that plays critical roles in many life processes. Controlling the cellular concentration and trafficking of copper offers a route to disrupt these processes. Here we report small m...
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Article
Selective fluorescent probes for live-cell monitoring of sulphide
Aqueous sulphides, including hydrogen sulphide, have important roles in biological signalling and metabolic processes. Here we develop a selective sulphide-trap** strategy involving sulphide addition to an a...
