67 Result(s)

Article

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control

Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation. Although the Fibron...

Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, ** Wang, Shenghao Zhang… in Cell Death & Disease (2024)

Article

ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especia...

Tianyao Liu, **nyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu… in Cell Death & Disease (2023)

Article

Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells

Gasdermin D (GSDMD) is a critical mediator of pyroptosis, which consists of a N-terminal pore-forming domain and a C-terminal autoinhibitory domain. Its cytolytic activity is sequestered by the intramolecular ...

**ufeng Chu, **ang **ao, Guangchuan Wang, Ahmed Uosef, **aohua Lou… in Cell Death & Disease (2023)

Article

TIGIT, a novel immune checkpoint therapy for melanoma

Melanoma is the most aggressive and deadliest type of skin cancer. In the last 10 years, immune checkpoint blockades (ICBs) including PD-1/PD-L1 and CTLA-4 inhibitor has been shown to be effective against mela...

Wei Tang, Jun Chen, Tianlong Ji, **ufeng Cong in Cell Death & Disease (2023)

Article

SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was ...

Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv… in Cell Death & Disease (2023)

Article

High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has elicited a worldwide pandemic since late 2019. There has been ~675 million confirmed coronavirus disease 2019 (COVID-19) cases, leadin...

Yufeng Luo, Shuo Liu, Jiguo Xue, Ye Yang, Junxuan Zhao, Ying Sun… in Cell Discovery (2023)

Article

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m⁵C methylation

5-methylcytosine (m⁵C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been p...

Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, **aoxiao Liang… in Cell Death & Disease (2023)

Article

BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids

Esophageal squamous cell carcinoma (ESCC) is one of the fatal malignancies worldwide. It has an increased propensity to metastasize via lymphogenous routes in an early stage. The prognosis of patients with lym...

**ufeng **e, Lusong Tian, Yan Zhao, Fang Liu, Shuyang Dai… in Cell Death & Disease (2023)

Article

4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer

Nutrient-limiting conditions are common during cancer development. The coordination of cellular glucose levels and cell survival is a fundamental question in cell biology and has not been completely understood...

Yanan Wang, Jiapeng Lei, Song Zhang, **aomei Wang, Jiangbo **… in Cell Death & Disease (2022)

Article

Insights into divalent cation regulation and G₁₃-coupling of orphan receptor GPR35

Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes G_s, G_i/o, and G_q/11, insuff...

Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan… in Cell Discovery (2022)

Article

BTN3A1 promotes tumor progression and radiation resistance in esophageal squamous cell carcinoma by regulating ULK1-mediated autophagy

Radiotherapy is one of the most effective treatments for esophageal squamous cell carcinoma (ESCC); however, radioresistance is a clinical problem that must urgently be solved. Here, we found that butyrophilin...

Wen**g Yang, Bo Cheng, Pengxiang Chen, **aozheng Sun, Zhihua Wen… in Cell Death & Disease (2022)

Article

Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening

Current non-invasive prenatal screening (NIPS) analyzes circulating fetal cell-free DNA (cfDNA) in maternal peripheral blood for selected aneuploidies or microdeletion/duplication syndromes. Many genetic disor...

Chenming Xu, Jianli Li, Songchang Chen, **aoqiang Cai, Ruilin **g… in Cell Discovery (2022)

Article

Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage

Proteinuria, an indication of kidney disease, is caused by the malfunction of podocytes, which play a key role in maintaining glomerular filtration. Angiopoietin-like 3 (ANGPTL3) has been documented to have a ...

Qianying Lv, **nli Han, Jiajia Ni, Qianqian Ma, Rufeng Dai… in Cell Death & Disease (2022)

Article

Correction: Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma

Yufeng Wang, Liankang Sun, Liang Wang, Zhikui Liu, Qing Li… in Cell Death & Disease (2022)

Article

Cytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib

The incidence of hepatocellular carcinoma (HCC) is increasing in the world. However, its role and underlying molecular mechanism in HCC progression remain unclear. We found that CYB5A plays a key role in HCC m...

Hongrui Guo, Shuhang Liang, Yan Wang, Shuo Zhou, Dalong Yin… in Cell Death & Disease (2022)

Article

Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s

The Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the receptor-binding domain (RBD) of the spike (S) protein. Moreover, host-adapting mutations, such as residues 493, 498, a...

Linjie Li, Pu Han, Baihan Huang, Yufeng **e, Weiwei Li, Di Zhang… in Cell Discovery (2022)

Article

GITR/GITRL reverse signalling modulates the proliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylate ERK1/2 and Akt

Hepatic stem/progenitor cells are the major cell compartment for tissue repair when hepatocyte proliferation is compromised in chronic liver diseases, but the expansion of these cells increases the risk of car...

Yu He, Yufeng Pei, Kai Liu, Lin Liu, Yue Tian, Hongyi Li, Min Cong… in Cell Death & Disease (2022)

Article

TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells

The incidence of lung cancer is increasing worldwide. Although great progress in lung cancer treatment has been made, the clinical outcome is still unsatisfactory. Tripartite motif (TRIM)-containing proteins h...

Jicheng Tantai, Xufeng Pan, Yong Chen, Yuzhou Shen, Chunyu Ji in Cell Death & Disease (2022)

Article

DdCBE-mediated mitochondrial base editing in human 3PN embryos

**aoxu Chen, Dong Liang, Jiayin Guo, Junqiang Zhang, Haifeng Sun… in Cell Discovery (2022)