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Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract
Cataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we found that the expression level of miR-204-5p was diminished in the len...
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Article
Open AccessElectronic inhomogeneity and phase fluctuation in one-unit-cell FeSe films
One-unit-cell FeSe films on SrTiO3 substrates are of great interest owing to significantly enlarged pairing gaps characterized by two coherence peaks at ±10 meV and ±20 meV. In-situ transport measurement is desir...
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Open AccessCyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts
Osteoporosis is a genetic disease caused by the imbalance between osteoblast-led bone formation and osteoclast-induced bone resorption. However, further gene-related pathogenesis remains to be elucidated.
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First report of tomato mosaic virus infecting Atropa belladonna in China
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Article
Relative order constraint for monocular depth estimation
Monocular depth estimation, which is playing an increasingly important role in 3D scene understanding, has been attracting increasing attention in the computer vision field in recent years. The latest monocula...
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Article
Effects of different metal electrodes on the ferroelectric properties of HZO thin films
Hafnium dioxide (HfO2)-based ferroelectric films are highly desirable due to their excellent compatibility with CMOS technology, good scalability, low operating voltage, and moderate polarization strength. Howeve...
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Recent progress in ferroelectric synapses and their applications
Brain-like computing is an important direction for the development of integrated circuits in the post-Moore era, and the development of artificial synaptic devices that can simulate ideal synaptic behavior is ...
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Article
Open AccessMolecular beam epitaxy growth of few-layer stanene
Two-dimensional topological materials, especially quantum spin Hall insulators, have attracted enormous research interest owing to their potential for applications ranging from low-power electronics to fault-t...
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Ambi-chiral anomalous Hall effect in magnetically doped topological insulators
The chirality associated with broken time-reversal symmetry in magnetically doped topological insulators has important implications for the quantum transport phenomena. Here we report anomalous Hall effect stu...
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Open AccessExplore potential disease related metabolites based on latent factor model
In biological systems, metabolomics can not only contribute to the discovery of metabolic signatures for disease diagnosis, but is very helpful to illustrate the underlying molecular disease-causing mechanism....
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Open AccessCNN-DDI: a learning-based method for predicting drug–drug interactions using convolution neural networks
Drug–drug interactions (DDIs) are the reactions between drugs. They are compartmentalized into three types: synergistic, antagonistic and no reaction. As a rapidly develo** technology, predicting DDIs-associ...
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Open AccessA multi-network integration approach for measuring disease similarity based on ncRNA regulation and heterogeneous information
Measuring similarity between complex diseases has significant implications for revealing the pathogenesis of diseases and development in the domain of biomedicine. It has been consentaneous that functional ass...
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Ex vivo evaluation of blood coagulation on endothelial glycocalyx-inspired surfaces using thromboelastography
Present blood-contacting materials have not yet demonstrated to be effective in reducing blood coagulation without causing additional side effects clinically. We have developed an endothelial glycocalyx-inspir...
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Article
Open AccessDRACP: a novel method for identification of anticancer peptides
Millions of people are suffering from cancers, but accurate early diagnosis and effective treatment are still tough for all doctors. Common ways against cancer include surgical operation, radiotherapy and chem...
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Open AccessdeSALT: fast and accurate long transcriptomic read alignment with de Bruijn graph-based index
The alignment of long-read RNA sequencing reads is non-trivial due to high sequencing errors and complicated gene structures. We propose deSALT, a tailored two-pass alignment approach, which constructs graph-b...
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Open AccessLncDisAP: a computation model for LncRNA-disease association prediction based on multiple biological datasets
Over the past decades, a large number of long non-coding RNAs (lncRNAs) have been identified. Growing evidence has indicated that the mutation and dysregulation of lncRNAs play a critical role in the developme...
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Open AccessIdentifying Alzheimer’s disease-related proteins by LRRGD
Alzheimer’s disease (AD) imposes a heavy burden on society and every family. Therefore, diagnosing AD in advance and discovering new drug targets are crucial, while these could be achieved by identifying AD-re...
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Open AccessPrioritizing candidate diseases-related metabolites based on literature and functional similarity
As the terminal products of cellular regulatory process, functional related metabolites have a close relationship with complex diseases, and are often associated with the same or similar diseases. Therefore, i...
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Open AccessHuman mitochondrial genome compression using machine learning techniques
In recent years, with the development of high-throughput genome sequencing technologies, a large amount of genome data has been generated, which has caused widespread concern about data storage and transmissio...
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First report of beet western yellows virus infecting tomato in China