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Article
Open AccessComparison of the efficacy and safety of ciprofol and propofol in sedating patients in the operating room and outside the operating room: a meta-analysis and systematic review
As a new type of intravenous anesthetic, ciprofol has the advantages of fast onset of action, fast recovery and high clearance rate. This study aimed to investigate the effectiveness and safety of ciprofol ver...
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Article
A small-molecule activation mechanism that directly opens the KCNQ2 channel
Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for therapy and mainly involves a classic gating mechanism that augments the native voltage-dependent open probability. T...
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Article
Association of Crohn’s disease and ulcerative colitis with the risk of neurological diseases: a large-scale Mendelian randomization study
Observational studies suggested increased risks of Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS) in patients with Crohn’s disease (CD) and ulcerative colitis (UC). We aimed to...
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Article
Open AccessAssociations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis
Computer gaming has recently been suggested to be associated with benefits for cognition, but its impact on incident dementia remains uncertain. We aimed to investigate the observational associations of playin...
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Article
Coupling of environmental factors and growth stages in simulation of maize biomass allocation
The patterns of biomass allocation are particularly important because it is related to crop yield, plant growth rate and plant survival in a changeable environment and constant growth. Our study aimed to deve...
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Article
Comparative Transcriptome Analysis Reveals the Complex Molecular Mechanisms Underlying Ultraviolet-B Tolerance in Brassica rapa var. rapa
In the agricultural areas of the Qinghai-Tibet Plateau, ultraviolet-B (UV-B) radiation varies widely. UV-B can affect the growth and development of plants. Turnip (Brassica rapa var. rapa) is an important traditi...
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Article
Open AccessGnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression
Vascular endothelial growth factor (VEGF) signaling pathway plays an important role in the progression of diabetic retinopathy (DR). The glycosylation modification process of many key functional proteins in DR...
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Article
Open AccessComparison of long-term radial artery occlusion via distal vs. conventional transradial access (CONDITION): a randomized controlled trial
The distal transradial access (dTRA) has become an attractive and alternative access to the conventional transradial access (TRA) for cardiovascular interventional diagnosis and/or treatment. There was a lack ...
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Article
Automatic text summarization for government news reports based on multiple features
The purpose of government news summarization is to extract the most important information from official government news reports. It is important for readers to be able to understand government news quickly in ...
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Article
Open AccessChromosome-level genome assembly of Hippophae gyantsensis
Hippophae gyantsensis, which is a native tree species in China, is ideal for windbreak and sand-fixing forests. It is an economically and ecologically valuable tree species distributed exclusively in the Qinghai-...
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Article
Open AccessIndividual-level patterns of resource selection do not predict hotspots of contact
Contact among animals is crucial for various ecological processes, including social behaviors, disease transmission, and predator–prey interactions. However, the distribution of contact events across time and ...
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Article
Open AccessLigand activation mechanisms of human KCNQ2 channel
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their act...
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Article
Open AccessDivergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice
The anterior disc displacement (ADD) leads to temporomandibular joint osteoarthritis (TMJOA) and mandibular growth retardation in adolescents. To investigate the potential functional role of fibrocartilage ste...
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Article
A Fast Adaptive Online Gradient Descent Algorithm in Over-Parameterized Neural Networks
In recent years, deep learning has dramatically improved state of the art in many practical applications. However, this utility is highly dependent on fine-tuning of hyperparameters, including learning rate, b...
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Article
Au Nanoparticles Loaded Bi5Ti3FeO15 Ferroelectric Nanosheets with Enhanced Photocatalytic Activity for NO Removal
Bi5Ti3FeO15 ferroelectric nanosheets are synthesized by molten salt method and further decorated Au nanoparticles on the surface of nanosheets by chemical reduced method. The phase structure, morphology, and opti...
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Article
Open AccessInformation interaction and social support: exploring help-seeking in online communities during public health emergencies
During public health emergencies, online community users can obtain social support and assistance through information interaction in the online community. This study takes the COVID-19 pandemic as the context ...
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Article
Open AccessChromosome-level genome assembly of Murraya paniculata sheds light on biosynthesis of floral volatiles
Murraya paniculata (L.) Jack, commonly called orange jessamine in the family Rutaceae, is an important ornamental plant in tropical and subtropical regions which is famous for its strong fragrance. Although genom...
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Article
Open AccessBudget Impact Analysis of REBYOTA™ (Fecal Microbiota, Live-jslm [FMBL]) for Preventing Recurrent Clostridioides difficile Infection in the US
Patients with Clostridioides difficile infection (CDI) often experience recurrences (rCDI), which are associated with high morbidity, mortality, and healthcare expenditures. REBYOTA™ (fecal microbiota, live-jslm ...
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Article
Open AccessCost-Effectiveness Analysis of REBYOTA™ (Fecal Microbiota, Live-jslm [FMBL]) Versus Standard of Care for the Prevention of Recurrent Clostridioides difficile Infection in the USA
Recurrent Clostridioides difficile infection (rCDI) is common and associated with considerable clinical and economic consequences. REBYOTA™ (fecal microbiota, live-jslm [FMBL]) is a microbiota-based live biothera...
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Article
Associations of Rheumatoid Factor, Rheumatoid Arthritis, and Interleukin-6 Inhibitor with the Prognosis of Ischemic Stroke: a Prospective Multicenter Cohort Study and Mendelian Randomization Analysis
Rheumatoid factor (RF), an established diagnostic biomarker for rheumatoid arthritis (RA), is associated with cardiovascular diseases, but its impact on clinical outcomes of ischemic stroke remains unclear. We...
