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Article
Open AccessNanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This review discusses the utilization...
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Article
Open AccessCost-effectiveness of talazoparib for patients with germline BRCA1/2 mutated HER2-negative advanced breast cancer in China and the US
Breast cancer is one of the tumors with the highest prevalence rate among women in the world, and its BRCA1/2 gene is a common mutation site. Talazoparib, as a targeted PARP inhibitor, can effectively control ...
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Article
Open AccessCkip-1 3’UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway
Sleep deprivation (SD) has emerged as a critical concern impacting human health, leading to significant damage to the cardiovascular system. However, the underlying mechanisms are still unclear, and the develo...
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Article
Open Access**nbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism
Heart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. **nbao Pill (XBW), a traditional Chinese medicine formulation integrating “Liushen Pill” and “Shenfu Decoction,” has been a...
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Article
Open AccessPhysicians’ understanding of antibiotic intravenous-to-oral switching—a qualitative study in Suzhou, China
The implementation of antibiotic intravenous-to-oral switch (IVOS) therapy in hospitals can slow down the development of drug resistance, reduce the occurrence of adverse reactions, and bring significant econo...
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Article
Open AccessDevelo** hydrogels for gene therapy and tissue engineering
Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers for drugs. Gene therapy is highly specific and can overcome the limitations of traditio...
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Article
Open AccessMating harassment may boost the effectiveness of the sterile insect technique for Aedes mosquitoes
The sterile insect technique is based on the overflooding of a target population with released sterile males inducing sterility in the wild female population. It has proven to be effective against several inse...
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Article
Open AccessBeyond text: Marketing strategy in a world turned upside down
Analyzing unstructured text, e.g., online reviews and social media, has already made a major impact, yet a vast array of publicly available, unstructured non-text data houses latent insight into consumers and ...
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Article
Open AccessRNA m6A methylation regulators in liver cancer
Liver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great development of diagnostic methods and targeted therapies for liver ca...
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Chapter and Conference Paper
Matching-to-Detecting: Establishing Dense and Reliable Correspondences Between Images
We present a novel view for local image feature matching, which is inspired by the difference between existing methods. Detector-based methods detect predefined keypoints in local regions, so that the stabilit...
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Article
Open AccessTemporal-spatial Generation of Astrocytes in the Develo** Diencephalon
Astrocytes are the largest glial population in the mammalian brain. However, we have a minimal understanding of astrocyte development, especially fate specification in different regions of the brain. Through l...
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Article
Ferroptosis: a new promising target for hepatocellular carcinoma therapy
Hepatocellular carcinoma (HCC) is the sixed most common malignant tumor in the world. The study for HCC is mired in the predicament confronted with the difficulty of early diagnosis and high drug resistance, t...
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Article
Metabolome and Transcriptome Association Analysis Reveals the Link Between Pigmentation and Nutrition Utilization in the Juveniles of Sea Cucumber Holothuria leucospilota
The sea cucumber Holothuria leucospilota is an economically and ecologically important tropical species. Following development into juveniles, H. leucospilota undergoes a color change from white to black, involvi...
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Article
Fostering sustainability: unveiling the impact of Internet development on carbon emissions in China
The rapid development of the Internet has significantly impacted various socio-economic activities. Using Chinese Industrial Enterprise database and Industrial Enterprise Pollution database, this research exam...
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Article
Open AccessDual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to targ...
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Article
Open AccessHuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast function play critical roles in bone formation, which is a highly regulated process. Long noncoding RNAs (lncRNAs) perform div...
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Article
Open AccessHemostatic effect and safety evaluation of oxidized regenerated cellulose in total knee arthroplasty- a randomized controlledtrial
Oxidized regenerated cellulose (ORC) is a type of biodegradable hemostatic material, which has been widely used in the field of surgery. However, its hemostatic effect in patients undergoing total knee arthrop...
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Article
Applications of Environmental DNA (eDNA) in Monitoring the Endangered Status and Evaluating the Stock Enhancement Effect of Tropical Sea Cucumber Holothuria Scabra
The tropical sea cucumber Holothuria scabra is naturally found in the Indo-West Pacific. However, due to their commercial value, natural H. scabra populations have declined significantly in recent years, resultin...
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Article
Extracting and supplementing method for EEG signal in manufacturing workshop based on deep learning of time–frequency correlation
The quality of EEG signals is extremely important for brain–computer interface systems, especially in complex environments such as manufacturing floors. At present, there are few studies on the recovery method...
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Article
Targeting CXCL9/10/11–CXCR3 axis: an important component of tumor-promoting and antitumor immunity
Chemokines are chemotactic-competent molecules composed of a family of small cytokines, playing a key role in regulating tumor progression. The roles of chemokines in antitumor immune responses are of great in...
