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Article
Open AccessPhysicians’ understanding of antibiotic intravenous-to-oral switching—a qualitative study in Suzhou, China
The implementation of antibiotic intravenous-to-oral switch (IVOS) therapy in hospitals can slow down the development of drug resistance, reduce the occurrence of adverse reactions, and bring significant econo...
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Article
Open AccessRole of metabolomic profile as a potential marker to discriminate membranous nephropathy from IgA nephropathy
Membranous nephropathy (MN) and IgA nephropathy (IgAN) are the most common primary glomerulopathies worldwide. The systemic metabolic changes in the progression of MN and IgAN are not fully understood.
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Article
Open AccessThe EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury
Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying mechanisms are still not fully understood. Our study has revealed...
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Article
Open AccessHucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and Oocytes
Follicle developmental capacity and oocyte quality decline with advanced maternal age. Extracellular vesicles from human umbilical cord mesenchymal stem cells (HucMSC-EVs) act as a potential therapeutic produc...
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Article
Dabigatran plasma concentration indicated the risk of patients with non-valvular atrial fibrillation
This study aimed to evaluate the variability of dabigatran plasma concentration and the association with clinical events in Chinese patients treated with dabigatran etexilate (DE) for non-valvular atrial fibri...
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Article
UFBP1, a key component in ufmylation, enhances drug sensitivity by promoting proteasomal degradation of oxidative stress-response transcription factor Nrf2
The key component in the UFM1 conjugation system, UFM1-binding and PCI domain-containing protein 1 (UFBP1), regulates many biological processes. Recently it has been shown that low UFBP1 protein level is assoc...
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Article
The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation
The ubiquitin proteasome system (UPS) plays important roles in the regulation of protein stability, localization, and activity. A myriad of studies have focused on the functions of ubiquitin ligases E3s and de...
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Article
Open AccessAn Improved Ranking Strategy for Fuzzy Multiple Attribute Group Decision Making
In this paper, we develop an improved ranking strategy for fuzzy multiple attribute group decision making. First, we introduce a method for multiple attribute group decision making and show that method can not...
