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Article
Open AccessStructural basis for urate recognition and apigenin inhibition of human GLUT9
Urate, the physiological form of uric acid and a potent antioxidant in serum, plays a pivotal role in scavenging reactive oxygen species. Yet excessive accumulation of urate, known as hyperuricemia, is the pri...
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Article
Author Correction: Cryo-EM structures of apo and antagonist-bound human Cav3.1
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Article
Physiological principles underlying the kidney targeting of renal nanomedicines
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality, highlighting a need for new therapeutic options. Engineered nanoparticles for the trea...
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Article
Reconciling grain production and environmental costs during rural livelihood transitions: a simulation-based approach in southern China
Tension is building up between the need to provide food for eight billion humans and the necessity to safeguard their environment. In many parts of the world, the ongoing transition of farmers’ livelihoods is ...
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Article
Interventions to Improve Adherence to Oral Pre-exposure Prophylaxis: A Systematic Review and Network Meta-analysis
For people at risk of HIV infection, pre-exposure prophylaxis (PrEP) can reduce the risk of infection in anticipation of exposure to HIV. The effectiveness of PrEP relies upon a user’s adherence to their PrEP ...
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Article
Energy transformation technology innovation finance: entrepreneurial capital and crowdfunding
Examines the dynamic funding interaction for innovation, entrepreneurship, and renewable energy technology. This study, conducted across ten developed countries between 1994 and 2018, employs the Moments Quant...
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Article
Open AccessIL-37 ameliorates myocardial fibrosis by regulating mtDNA-enriched vesicle release in diabetic cardiomyopathy mice
Diabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities of the heart and ultimately evolves to heart failure. IL-37 exerts a substantial influence on...
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Article
Functions of violaxanthin de-epoxidase-related (VDR) in the photoprotective response to high-light stress
The xanthophyll cycle plays a pivotal role in protecting plants and algae against photodamage. Although the resistance of the violaxanthin de-epoxidase enzyme (VDE) to high light stress in the xanthophyll cycl...
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Article
Open AccessSuperconductivity of thulium substituted clathrate hexahydrides at moderate pressure
Due to the BCS theory, hydrogen, the lightest element, would be the prospect of room-temperature superconductor after metallization, but because of the difficulty of the hydrogen metallization, the theory abou...
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Article
Open AccessIdentification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives
Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains...
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Article
Open AccessSlee** more than 8 h: a silent factor contributing to decreased muscle mass in Chinese community-dwelling older adults
Muscle mass loss is an age-related process that can be exacerbated by lifestyle, environmental and other factors, but can be mitigated by good sleep. The objective of this study was to investigate the correlat...
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Article
Advantages of robot-assisted resection of large mediastinal tumors: a single-center preliminary study
Current study aims to assess the safety and efficacy of robot-assisted thoracoscopic surgery (RATS) for sizable mediastinal masses with a minimum diameter ≥6 cm, compared with video-assisted thoracoscopic surg...
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Article
Hierarchical model updating for high-speed maglev vehicle/guideway coupled system based on multi-objective optimization
The high-speed maglev vehicle/guideway coupled model is an essential simulation tool for investigating vehicle dynamics and mitigating coupled vibration. To improve its accuracy efficiently, this study investi...
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Article
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
Systemic lupus erythematosus (SLE) and the Epstein-Barr virus (EBV) are very closely related. This study estimated the impact of EBV infection status on clinical manifestations and disease remission in patient...
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Article
Low-resolution Kramers-Kronig detection system with error-feedback noise sha**
In this paper, we investigated the effects of error-feedback noise sha** (EFNS) on a low-resolution Kramers-Kronig (KK) detection system for the first time. Both 16-ary quadrature amplitude modulation (16-QA...
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Article
Open AccessIntegrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new disciplines in systems biology aimed to discove...
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Article
Open AccessLow platelet count at diagnosis of anti-neutrophil cytoplasmic antibody-associated vasculitis is correlated with the severity of disease and renal prognosis
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease that involves inflammation of blood vessels. There is increasing evidence that platelets play a crucial role not only in...
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Article
Differential expression of follicular fluid exosomal microRNA in women with diminished ovarian reserve
Decreased ovarian reserve function is mainly characterized by female endocrine disorders and fertility decline. Follicular fluid (FF) exosomal microRNAs (miRNAs) have been shown to regulate the function of gra...
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Article
Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps
The treatment of eosinophilic chronic rhinosinusitis with nasal polyps (E-CRSwNP) remains a challenge due to its complex pathogenesis. Inositol polyphosphate-4-phosphatase type IA (INPP4A), a lipid phosphatase...
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Article
Highly efficient and stable electrocatalyst for hydrogen evolution by molybdenum doped Ni-Co phosphide nanoneedles at high current density
There is an increasingly urgent need to develop cost-effective electrocatalysts with high catalytic activity and stability as alternatives to the traditional Pt/C in catalysts in water electrolysis. In this st...
