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Article
Open AccessLABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA
Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...
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Article
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
Systemic lupus erythematosus (SLE) and the Epstein-Barr virus (EBV) are very closely related. This study estimated the impact of EBV infection status on clinical manifestations and disease remission in patient...
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Article
An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer
Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate tumorigenesis, but the mechanisms underlying their dysregula...
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Article
Open AccessNew strategy for intraoperative phonosurgical management of recurrent laryngeal nerve infiltrated by thyroid carcinoma
Treating an infiltration of the recurrent laryngeal nerve (RLN) by thyroid carcinoma remains a subject of ongoing debate. Therefore, this study aims to provide a novel strategy for intraoperative phenosurgical...
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Article
Open AccessThe association between variability of risk factors and complications in type 2 diabetes mellitus: a retrospective study
The variability in diabetes risk factors, such as uric acid and lipids, may influence the development of complications. This study aimed to investigate the influence of such variability on the occurrence of di...
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Article
Process Optimization for Ionic Liquid Tetrabutylammonium Hydroxide Pretreatment of Waste Particleboard to Heighten Enzymatic Hydrolysis Saccharification
The dense lignocellulosic structure inherent in particleboard poses a challenge to its efficient energy utilization, necessitating pretreatment prior to use. This study is aimed at exploring an optimal ionic l...
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Article
Effect of continuous hypertonic saline infusion on clinical outcomes in patients with traumatic brain injury
Osmotic therapy has been recognized as an important treatment option for patients with traumatic brain injury (TBI). Nevertheless, the effect of hypertonic saline (HTS) remains unknown, as findings are primari...
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Article
Value of painless transvaginal four-dimensional hysterosal**o contrast sonography in reducing venous intravasation: a comparative study
To investigate the value of painless transvaginal four-dimensional hysterosal**o contrast sonography (TV 4-D HyCoSy) in reducing venous intravasation and its influencing factors through a retrospective compa...
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Article
A novel CD47-blocking peptide fused to pro-apoptotic KLA repeat inhibits lung cancer growth in mice
CD47 is highly expressed in many tumor tissues and induces immune evasion by interaction with SIRP-alpha (signal regulatory protein-alpha) expressed on tumor-associated macrophages. In this study, we identifie...
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Open AccessIntegration of risk variants from GWAS with SARS-CoV-2 RNA interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19
The role of host genetic factors in COVID-19 outcomes remains unclear despite various genome-wide association studies (GWAS). We annotate all significant variants and those variants in high LD (R2 > 0.8) from the...
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Article
Open AccessA new Bayesian factor analysis method improves detection of genes and biological processes affected by perturbations in single-cell CRISPR screening
Clustered regularly interspaced short palindromic repeats (CRISPR) screening coupled with single-cell RNA sequencing has emerged as a powerful tool to characterize the effects of genetic perturbations on the w...
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Article
Research Advances of Mitochondrial Dysfunction in Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorders (PND) increases postoperative dementia and mortality in patients and has no effective treatment. Although the detailed pathogenesis of PND is still elusive, a large amoun...
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Article
The Role of PGC-1α-Mediated Mitochondrial Biogenesis in Neurons
Neurons are highly dependent on mitochondrial ATP production and Ca2+ buffering. Neurons have unique compartmentalized anatomy and energy requirements, and each compartment requires continuously renewed mitochond...
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Article
Open AccessRBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
N6-methyladenosine (m6A) methylation can be deposited on chromatin-associated RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state and transcription. However, the mechanism by whic...
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Article
Open AccessEfficacy of a smartphone application for hel** individuals with type 2 diabetes mellitus manage their blood glucose: a protocol for factorial design trial
China has the largest number of individuals with type 2 diabetes mellitus (T2DM) in the world, and most lack knowledge about glycemic control and health management. This trial will examine whether a smartphone...
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Article
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
N6-methyladenosine (m6A), the most abundant internal messenger RNA modification in higher eukaryotes, serves myriad roles in regulating cellular processes. Functional dissection of m6A is, however, hampered in pa...
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Article
circRNA-miRNA-mRNA network analysis to explore the pathogenesis of abnormal spermatogenesis due to aberrant m6A methylation
Many studies have shown that circRNAs and miRNAs play important roles in many different life processes. However, the function of circRNAs in spermatogenesis remains unknown. Here, we aimed to explore the mecha...
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Article
Open Access3D genomics and its applications in precision medicine
Three-dimensional (3D) genomics is an emerging discipline that studies the three-dimensional structure of chromatin and the three-dimensional and functions of genomes. It mainly studies the three-dimensional c...
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Article
Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
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Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade
Over 500 clinical trials are investigating combination radiotherapy and immune checkpoint blockade (ICB) as cancer treatments; however, the majority of trials have found no positive interaction. Here we perfor...
