897 Result(s)

Article

A new pressure measuring system for cushions and beds—with a review of the literature

An interface pressure measuring device for the assessment of subject-cushion interface pressures at ten points has been described. Preliminary trials using 12 healthy subjects on four cushions and three spinal...

L K Holley, J Long, J Stewart, R F Jones in Spinal Cord (1979)

Article

Molecules versus morphology: the detection of selection acting on morphological characters along a cline in Drosophila melanogaster

This work examines the nature of north-south clinal variation in morphological characters in Drosophila melanogaster. Isofemale lines were established from flies collected along a transect extending from Winnipeg...

Anthony Douglas Long, Rama S Singh in Heredity (1995)

Article

Erratum: Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

Nat. Neurosci. 2, 226– 233 (1999) On page 229, Fig. 4a–c reproduced poorly because of a printer's error. The correct version is below.

Hai-Long Wang, Margherita Milone, Kinji Ohno, **ng-Ming Shen… in Nature Neuroscience (1999)

Article

Effects of new 17α-hydroxylase/C_17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo

Our laboratory has been develo** new inhibitors of a key regulatory enzyme of testicular and adrenal androgen synthesis 17α-hydroxylase/C_17,20-lyase (P450c17), with the aim of improving prostate cancer treatmen...

D N Grigoryev, B J Long, I P Nnane, V C O Njar, Y Liu… in British Journal of Cancer (1999)

Article

Anti-tumour effects and pharmacokinetic profile of 17-(5′-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis

17-(5′-Isoxazolyl)androsta-4,16-dien-3-one (L-39), a novel androstene derivative, was synthesized and evaluated in vitro and in vivo. L-39 showed potent and non-competitive inhibition of human testicular micro...

I P Nnane, B J Long, Y-Z Ling, D N Grigoryev, A M Brodie in British Journal of Cancer (2000)

Article

Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice

Experimental infection with enterovirus type 71 (EV71) induced death in neonatal mice in an age- and dose-dependent manner. The mortality rate was 100% following intraperitoneal inoculation 1-day-old ICR mice ...

Dr. Chun-Keung Yu, Chi-Chung Chen, Chi-Long Chen… in Journal of Biomedical Science (2000)

Article

New nomenclature for MHC receptors

P. André, R. Biassoni, M. Colonna, D. Cosman, L. L. Lanier, E. O. Long… in Nature Immunology (2001)

Article

Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris

Rhodopseudomonas palustris is among the most metabolically versatile bacteria known. It uses light, inorganic compounds, or organic compounds, for energy. It acquires carbon from many types of green plant–derived...

Frank W Larimer, Patrick Chain, Loren Hauser, Jane Lamerdin… in Nature Biotechnology (2004)

Article

Evaluation of safety and efficacy of gefitinib ('iressa', zd1839) as monotherapy in a series of Chinese patients with advanced non-small-cell lung cancer: experience from a compassionate-use programme

The gefitinib compassionate-use programme has enabled >39,000 patients worldwide to receive gefitinib ('Iressa', ZD1839) treatment. This paper reports the outcome of gefitinib treatment in Chinese patients who...

**n-Lin Mu, Long-Yun Li, **ao-Tong Zhang, Shu-Lan Wang, Meng-Zhao Wang in BMC Cancer (2004)

Article

Alteration of binding sites for [³H]P1075 and [³H]glibenclamide in renovascular hypertensive rat aorta

The alterations of the binding sites for ATP-sensitive K⁺ channel (K_ATP) openers and blockers in aortic strips were investigated in hypertensive rats.

Hua-mei He, Chao-liang Long, Le-zhi Zhang, Ai-ling Fu… in Acta Pharmacologica Sinica (2005)

Article

Pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes in mice

To study the pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes (5-Fu-GCL) in mice.

Yong **, Jun Li, Long-fu Rong, **ong-wen Lü, Yan Huang… in Acta Pharmacologica Sinica (2005)

Article

Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women

To evaluate whether estrogen receptor α (ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women.

Hong Xu, Ji-rong Long, Miao-xin Li, Hong-wen Deng in Acta Pharmacologica Sinica (2005)

Article

High-dose chemotherapy and peripheral blood stem cell support in refractory gestational trophoblastic neoplasia

We present retrospectively our experience in the use of high-dose chemotherapy and haematopoietic stem cell support (HSCS) for refractory gestational trophoblastic neoplasia (GTN) in the largest series so far ...

L M El-Helw, M J Seckl, R Haynes, L S Evans, P C Lorigan… in British Journal of Cancer (2005)

Article

Induction of liver cytochrome P450 1A2 expression by flutamide in rats

To investigate the modulation of liver cytochrome P450 1A2 (CYP1A2) expression by giving flutamide to adult rats.

Hai-xue Wang, **ao Liu, Chang-jiang Xu, **ao-chao Ma… in Acta Pharmacologica Sinica (2005)

Article

Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice

To investigate the protective effects of berberine on ethanol-induced gastric ulcer in mice.

Long-rui Pan, Qiang Tang, Qin Fu, Ben-rong Hu, Ji-zhou **ang… in Acta Pharmacologica Sinica (2005)

Article

C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats

Advanced glycation endproducts (AGE) have been implicated in the pathogenesis of diabetic complications, including diabetic cardiovascular dysfunction. 3-[2-(4-Bromo-phenyl)-1-methyl-2-oxo-ethyl]-4,5,6,7-tetra...

Gang Cheng, Li-li Wang, Wen-sheng Qu, Long Long, Hao Cui… in Acta Pharmacologica Sinica (2005)

Article

Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells

The present study was designed to further investigate the effect of connective tissue growth factor antisense oligonucleotide (CTGF-AS) on angiotensin II (Ang II)-induced tubular cell epithelial mesenchymal tr...

Long Chen, Bi-cheng Liu, **ao-liang Zhang, Jian-dong Zhang… in Acta Pharmacologica Sinica (2006)

Article

Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo

Bone morphogenetic protein 4 (BMP4) is one of the main local contributing factors in callus formation in the early phase of fracture healing. Adipose-derived stromal cells (ADSC) are multipotent cells. The pre...

Lin Lin, **n Fu, **n Zhang, Lian-xu Chen, Ji-ying Zhang… in Acta Pharmacologica Sinica (2006)

Article

Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes

To investigate whether hypoxia reoxygenation induces premature senescence in neonatal Sprague-Dawley (SD) rat cardiomyocytes.

Feng-xiang Zhang, Ming-long Chen, Qi-jun Shan, Jian-gang Zou… in Acta Pharmacologica Sinica (2007)

Article

A cell-based model of α-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease

To develop a cell-based model by stable transfection of SH-SY5Y with mutant A53T human α-synuclein, recapitulating neurotoxicity of α-synuclein overexpression.

Da-long Zhao, Li-bo Zou, Lan-fang Zhou, ** Zhu, Hai-bo Zhu in Acta Pharmacologica Sinica (2007)