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Article
Open AccessMultivariate Gene-Based Association Test on Family Data in MGAS
In analyses of unrelated individuals, the program multivariate gene-based association test by extended Simes (MGAS), which facilitates multivariate gene-based association testing, was shown to have correct Typ...
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Article
Open AccessEvaluating the effective numbers of independent tests and significant p-value thresholds in commercial genoty** arrays and public imputation reference datasets
Current genome-wide association studies (GWAS) use commercial genoty** microarrays that can assay over a million single nucleotide polymorphisms (SNPs). The number of SNPs is further boosted by advanced stat...
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Article
Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity
The purpose of the present study was to evaluate the magnitude of genetic determination of spine and hip bone mineral density (BMD) and body mass index (BMI), and to explore the genetic, environmental, and phe...
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Article
Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese
In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chin...
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Article
Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women
To evaluate whether estrogen receptor α (ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women.
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Article
The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families
Low peak bone density (PBD) in adulthood is an important determinant of osteoporotic fracture (OF) in the elderly. The tumor necrosis factor receptor 2 (TNFR2) gene has been considered as an important candidat...
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Article
Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population
Bone mineral density (BMD) is a significant determinant of risk for osteoporosis. Genetic factors are known to account for a major proportion of variation of BMD in Caucasians. However, the degree of genetic d...
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Article
The −1997 G/T Polymorphism in the COLIA1 Upstream Regulatory Region is Associated with Hip Bone Mineral Density (BMD) in Chinese Nuclear Families
Type I collagen is the most abundant protein of bone matrix, and the collagen type I alpha 1(COLIA1) gene has been considered one of the most important candidate genes for osteoporosis. In this study, we simultan...
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Article
Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women
In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a ma...
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Article
A major gene model of adult height is suggested in Chinese
Adult height (stature), as a complex quantitative trait, has been studied in different populations. However, few genetic studies on height were performed on the Chinese, the largest population in the world. In...
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Article
Bone mineral density in elderly Chinese: effects of age, sex, weight, height, and body mass index
To enhance our understanding of the relationship between bone mineral density (BMD) and sex, age, body mass index (BMI), weight, and height in elderly Chinese, we studied 258 males aged 50–80 years (mean ± SD,...
