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Article
Open AccessClinical development of mRNA therapies against solid tumors
The mRNA-based therapeutics have become the hot spot of biopharmaceutical industries in recent years. The landscape of this area is expanding from infectious disease to cancer, which needs to be summarized to ...
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Article
IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway
Upon chronic stress, β-adrenergic receptor activation induces cardiac fibrosis and leads to heart failure. The small molecule compound IMM-H007 has demonstrated protective effects in cardiovascular diseases vi...
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Article
Open AccessA report of nine cases and review of the literature of infertile men carrying balanced translocations involving chromosome 5
Balanced translocations may cause the loss of genetic material at the breakpoints and may result in failure of spermatogenesis. However, carriers of reciprocal translocation may naturally conceive. Genetic cou...
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Article
Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling
To investigate the protective effects of octacosanol in 6-hydroxydopamine-induced Parkinsonian rats and find whether octacosanol has effects on pro nerve growth factor (pro-NGF), NGF and the downstream effecto...
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Article
A cell-based model of α-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease
To develop a cell-based model by stable transfection of SH-SY5Y with mutant A53T human α-synuclein, recapitulating neurotoxicity of α-synuclein overexpression.
