22 Result(s)
within
English
Life Sciences
Cancer Research
Cell Biology
**na Hong
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Article
Open AccessHuman 14-3-3 gamma protein results in abnormal cell proliferation in the develo** eye of Drosophila melanogaster
14-3-3 proteins are a family of adaptor proteins that participate in a wide variety of cellular processes. Recent evidence indicates that the expression levels of these proteins are elevated in some human tumo...
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Erratum: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
Received 29 October 2008; accepted 19 February 2009; published online 17 May 2009; corrected after print 19 May 2009 In the version of this article initially published, the Myc–Ub label in Figure 3c was incorr...
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Open AccessProteomics, pathway array and signaling network-based medicine in cancer
Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying prot...
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p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
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Erratum: p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
Nat. Cell Biol. 13, 317–323 (2011); published online 20 February 2011 In the version of this article initially published online and in print, Figs 2b and 4a contained panels that did not match those in Supplem...
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Erratum: Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis
Nat. Cell Biol. 15, 40–49 (2013); published online 16th December 2012; corrected online 20th December 2012 In the version of this Article initially published online and in print, the protein WAPL was mistakenl...
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Correction: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming
Nat. Cell Biol. 17, 856–867 (2015); published online 22 June 2015; corrected after print 10 August 2015 In the version of this Article originally published, panels from Fig. 8e were mistakenly reproduced as Fi...
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Open AccessNew insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...
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A three-dimensional model of human lung development and disease from pluripotent stem cells
Chen et al. generate lung bud organoids from human pluripotent stem cells that recapitulate early lung development, such as branching airway formation and early alveolar structures, which could potentially be use...
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Open AccessSubunits of human condensins are potential therapeutic targets for cancers
The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are invol...
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Open AccessFGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway
Fibroblast growth factor (FGF) and tumor growth factor-β (TGFβ) have emerged as pivotal regulators during the progression of osteosarcoma (OS). LHX9 is one crucial transcription factor controlled by FGF, howev...
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Lipid transfer at ER–isolation membrane contacts
Hong Zhang highlights the emerging importance of lipid transfer proteins in autophagosome biogenesis.
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Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain
In patients with advanced-stage cancer, cancer-associated anorexia affects treatment success and patient survival. However, the underlying mechanism is poorly understood. Here, we show that Dilp8, a Drosophila ho...
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Open AccessRal GTPase is essential for actin dynamics and Golgi apparatus distribution in mouse oocyte maturation
Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane tran...
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Machinery, regulation and pathophysiological implications of autophagosome maturation
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome and subsequently delivered to lysosomes, where th...
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Open AccessROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
Reactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. ROMO1 regulates ROS generation with...
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Open AccessPan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends via alternative polyadenylation c...
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Open AccessDynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood. Here we discover a...
