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Genomic analysis uncovers that cold-inducible RNA binding protein is associated with estrogen receptor in breast cancer
RNA-binding proteins (RBPs) perform various biological functions in humans and are associated with several diseases, including cancer. Therefore, RBPs have emerged as novel therapeutic targets. Although recent...
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Article
Open AccessSAMD13 serves as a useful prognostic biomarker for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the 5-year relative overall survival (OS) rate is less than 20%. Since there are no specific symptoms, most patients with HCC are diag...
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Article
Thermo-hydraulic performance prediction for offset-strip fin heat exchangers using artificial neural networks
In this study, an artificial neural network (ANN) model was applied to predict the thermo-hydraulic performance of the offset-strip fin heat exchanger. The ANN model was used for predicting the thermo-hydrauli...
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Article
Open AccessA new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity
Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it is yet to be determined whether and how restriction of specific nutrients promote longevity. Previous genome-wide scr...
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Living Together with Unease—Koreans’ Perception of and Attitudes Toward Immigrants
Seokho Kim and So Hyun Park highlights that while Koreans acknowledge controls contributes to the economy by alleviating labor shortages, they still exhibit considerable concern that increased immigration ma...
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Article
Open AccessMolecular do** of nucleic acids into light emitting crystals driven by multisite-intermolecular interaction
We reveal the fundamental understanding of molecular do** of DNAs into organic semiconducting tris (8-hydroxyquinoline) aluminum (Alq3) crystals by varying types and numbers of purines and pyrimidines constitut...
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Article
Open AccessPancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor
Cancer cachexia is a highly debilitating condition characterized by weight loss and muscle wasting that contributes significantly to the morbidity and mortality of pancreatic cancer. The factors that induce ca...
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Article
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain
In patients with advanced-stage cancer, cancer-associated anorexia affects treatment success and patient survival. However, the underlying mechanism is poorly understood. Here, we show that Dilp8, a Drosophila ho...
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Article
Open AccessProgranulin attenuates liver fibrosis by downregulating the inflammatory response
Progranulin (PGRN) is a cysteine-rich secreted protein expressed in endothelial cells, immune cells, neurons, and adipocytes. It was first identified for its growth factor-like properties, being implicated in ...
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Article
45.5-tesla direct-current magnetic field generated with a high-temperature superconducting magnet
Strong magnetic fields are required in many fields, such as medicine (magnetic resonance imaging), pharmacy (nuclear magnetic resonance), particle accelerators (such as the Large Hadron Collider) and fusion de...
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Article
Open AccessAuthor Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
The original version of this Article contained errors in Figs. 4, 5, and 6. In Fig. 4d, the x-axis label incorrectly read ‘blank, +, blank, +’, and in Fig. 5e, the bars of the second graph from the left were colo...
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Article
Open AccessElevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer
Pancreatic adenocarcinoma upregulated factor (PAUF) is a ligand of toll-like receptors (TLRs) and has been reported to be involved in pancreatic tumor development. However, the significance of PAUF expression ...
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Article
Open AccessEstrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we ana...
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Article
Open AccessCTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors
CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently showed that CT...
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Article
Sharp and bright photoluminescence emission of single-crystalline diacetylene nanoparticles
Amorphous nanoparticles (NPs) of diacetylene (DA) molecules were prepared by using a reprecipitation method. After crystallization through a solvent-vapor annealing process, the highly crystalline DA NPs show ...
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Article
The polycystin complex mediates Wnt/Ca2+ signalling
WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2), a Ca2+-permeable ion channel. Inac...
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Article
Fabrication and Testing of a Prototype 10-kW Class HTS DC Induction Heating Machine
The authors presented practical fabricated specifications of a prototype 10kW class high-temperature superconductor (HTS) direct current (DC) induction heating machine and analyzed its operational characterist...
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Article
Design and AC Loss Analysis of a 22.9 kV/50 MVA Class Triaxial HTS Power Cable
Recently, triaxial high temperature superconducting (HTS) power cables have become a mainstream design in the development of HTS cables because of several advantages, such as the reduced amount of HTS wire, lo...
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Article
Personality and Subjective Well-Being: Evidence from South Korea
Although the statistically significant relationship between personality traits and subjective well-being (i.e., self-reported happiness and life satisfaction) is well-known in the field of positive psychology,...
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Patterns of Citizenship and Political Action in Korea, Germany and the United States: An Analysis of the 2004 ISSP Data
Although there is enormous interest in cross-national differences in the patterns of citizenship and political action as globalization accelerates, we know little about how and why they vary among nations. Thi...