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  1. No Access

    Article

    Combination of flavopiridol and embelin effectively inhibit cell growth in hepatocellular carcinoma depending on regulatory relationship between CDK6 and XIAP

    Flavopiridol, as a cyclin-dependent kinase (CDK) inhibitor, has entered into phase II study of clinical trial in chronic lymphocytic leukemia. In our study, flavopiridol decreased cell viability, significantly...

    Yufang Che, David Y. Zhang, Fei Ye, Benyan Wu, Bo Jiang in Medicinal Chemistry Research (2012)

  2. No Access

    Article

    PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation

    P21-activated protein kinase1 (PAK1), a main downstream effector of small Rho GTPases, Rac1, and Cdc42, plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis. Des...

    Haitao Qing, Wei Gong, Yufang Che, **nying Wang, Liang Peng, Yan Liang… in Tumor Biology (2012)

  3. Article

    Open Access

    Proteomics, pathway array and signaling network-based medicine in cancer

    Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying prot...

    David Y Zhang, Fei Ye, Ling Gao, **aoliang Liu, **n Zhao, Yufang Che… in Cell Division (2009)

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