297 Result(s)

Article

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

It has been suggested that overexpression of the Bcl-2 oncoprotein in human cancer cells contributes to their resistance to apoptosis induced by chemotherapy. We report here that a novel dipeptidyl proteasome ...

Bing An, Ronald H Goldfarb, Robert Siman, Q ** Dou in Cell Death & Differentiation (1998)

Article

Function and regulation of Aurora/Ipl1p kinase family in cell division

During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. ...

Yu Wen KE, Zhen DOU, Jie ZHANG, Xue Biao YAO in Cell Research (2003)

Article

Dynamic distribution of TTK in HeLa cells: insights from an ultrastructural study

Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fibe...

Zhen DOU, Akira SAWAGECHI, Jie ZHANG, Hong LUO, Lawrence BRAKO… in Cell Research (2003)

Article

Pattern similarity study of functional sites in protein sequences: lysozymes and cystatins

Although it is generally agreed that topography is more conserved than sequences, proteins sharing the same fold can have different functions, while there are protein families with low sequence similarity. An ...

Shuryo Nakai, Eunice CY Li-Chan, **glie Dou in BMC Biochemistry (2005)

Article

Corneal epithelial changes following reconstruction by transplantation of limbal stem cells in goats with total limbal stem cell deficiency

Shengli Mi, Zhongying Dou, Qingmei Zhao, Xueyi Yang, Lei Qu, Shuming Chen… in Cell Research (2008)

Article

Fetal porcine mesenchymal stem cells nuclear transfer and isolation of embryonic stem cells-like derived from cloned blastocysts

XM Xu, JL Hua, ZM Gao, AM Lei, XL Ma, CR Yang, JY Shi W Huang, JZ Fan… in Cell Research (2008)

Article

Characterization of growth and differentiation of goat limbal adult stem cells in vivo and ex vivo

Shengli Mi, Zhongying Dou, Qingmei Zhao, Xueyi Yang, Lei Qu, Shuming Chen… in Cell Research (2008)

Article

Serum free culture and characterization of human embryonic germ cells

**Lian Hua, Hai-sheng Yu, Sheng Liu, Zhongying Dou in Cell Research (2008)

Article

Isolation and characterization of mouse embryonic stem cell line by parthenogenesis

Shumin Yu, **nrong Yan, Dongmei Chen, Huayan Wang, Zhongying Dou in Cell Research (2008)

Article

Reconstruction of corneal epithelium with cryopreserved corneal limbal stem cells in a goat model

Shengli Mi, Zhongying Dou, Qingmei Zhao, Xueyi Yang, Lei Qu, Shuming Chen… in Cell Research (2008)

Article

Knock-down Nanog gene expression by siRNA affects the differentiation of cardiomyocytes in P19 cell

Lei Lei, Lin Dou, Huayan Wang in Cell Research (2008)

Article

Transplantation of ex vivo expanded stem cell amniotic sheet for ocular surface reconstruction

Shengli Mi, Zhongying Dou, Qingmei Zhao, Xueyi Yang, Lei Qu, Shuming Chen… in Cell Research (2008)

Article

Studying the unfolding process of protein G and protein L under physical property space

The studies on protein folding/unfolding indicate that the native state topology is an important determinant of protein folding mechanism. The folding/unfolding behaviors of proteins which have similar topolog...

Liling Zhao, Jihua Wang, **anghua Dou, Zanxia Cao in BMC Bioinformatics (2009)

Article

Fine-grained parallel RNAalifold algorithm for RNA secondary structure prediction on FPGA

In the field of RNA secondary structure prediction, the RNAalifold algorithm is one of the most popular methods using free energy minimization. However, general-purpose computers including parallel computers o...

Fei **a, Yong Dou, **ngming Zhou, Xuejun Yang, Jiaqing Xu, Yang Zhang in BMC Bioinformatics (2009)

Article

Global transcriptional analysis of nitrogen fixation and ammonium repression in root-associated Pseudomonas stutzeri A1501

Biological nitrogen fixation is highly controlled at the transcriptional level by regulatory networks that respond to the availability of fixed nitrogen. In many diazotrophs, addition of excess ammonium in the...

Yongliang Yan, Shuzhen **, Jun** Peng, Yunlei Han, Liang Li, Jian Yang… in BMC Genomics (2010)

Article

The complete mitochondrial genome of the citrus red mite Panonychus citri (Acari: Tetranychidae): high genome rearrangement and extremely truncated tRNAs

The family Tetranychidae (Chelicerata: Acari) includes ~1200 species, many of which are of agronomic importance. To date, mitochondrial genomes of only two Tetranychidae species have been sequenced, and it has...

Ming-Long Yuan, Dan-Dan Wei, Bao-Jun Wang, Wei Dou, **-Jun Wang in BMC Genomics (2010)

Article

Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin

**a Ding, Feng Yan, Phil Yao, Zhihong Yang, Weihong Wan, **wei Wang… in Cell Research (2010)

Article

Physiological levels of ATP negatively regulate proteasome function

Intracellular protein degradation by the ubiquitin-proteasome system is ATP dependent, and the optimal ATP concentration to activate proteasome function in vitro is ∼100 μM. Intracellular ATP levels are generally...

Hongbiao Huang, **aoyan Zhang, Shujue Li, Ningning Liu, Wen Lian… in Cell Research (2010)

Article

FPGA accelerator for protein secondary structure prediction based on the GOR algorithm

Protein is an important molecule that performs a wide range of functions in biological systems. Recently, the protein folding attracts much more attention since the function of protein can be generally derived...

Fei **a, Yong Dou, Guoqing Lei, Yusong Tan in BMC Bioinformatics (2011)

Article

New methods to measure residues coevolution in proteins

The covariation of two sites in a protein is often used as the degree of their coevolution. To quantify the covariation many methods have been developed and most of them are based on residues position-specific...

Hongyun Gao, Yongchao Dou, Jialiang Yang, Jun Wang in BMC Bioinformatics (2011)