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Open AccessStructural insights into human CCAN complex assembled onto DNA
In mitosis, accurate chromosome segregation depends on kinetochores that connect centromeric chromatin to spindle microtubules. The centromeres of budding yeast, which are relatively simple, are connected to i...
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Article
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis
Spindle position control is essential for cell fate determination and organogenesis. Early studies indicate the essential role of the evolutionarily conserved Gαi/LGN/NuMA network in spindle positioning. Howev...
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Article
NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation
Oriented cell divisions are controlled by a conserved molecular cascade involving Gαi, LGN, and NuMA. Here, we show that NDP52 regulates spindle orientation via remodeling the polar cortical actin cytoskeleton...
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Article
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation
The cell cycle regulator CDK1 phosphorylates the acetyltransferase TIP60, which subsequently acetylates the mitotic regulator Aurora B to ensure chromosomal segregation. Aurora B acetylation prevents inactivat...
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Article
Degree Theory and Solution Existence of Set-Valued Vector Variational Inequalities in Reflexive Banach Spaces
In this paper, a degree theory for set-valued vector variational inequalities is built in reflexive Banach spaces. By using the method of degree theory, some existence results of solutions for set-valued vecto...
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Article
Open AccessSpatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation
Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. The microtubule depolymerase mitotic centromere-associated kinesin (MCAK) is a ke...
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Article
Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin
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Mitotic Chromosome Segregation Control
The somatic division, called mitosis, is characterized by equal distribution of parental genome into two daughter cells. Mitosis involves a dramatic reorganization of both nucleus and cytoplasm driven by prote...
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Article
Dynamic distribution of TTK in HeLa cells: insights from an ultrastructural study
Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fibe...
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Article
Function and regulation of Aurora/Ipl1p kinase family in cell division
During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. ...
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Article
Protein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cells
Spindle checkpoint is an important biochemical signaling cascade during mitosis which monitors the fidelity of chromosome segregation, and is mediated by protein kinases Mps1 and Bub1/BubR1. Our recent studies...
