625 Result(s)
within
**hui Li
Life Sciences
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Article
Open AccessGenome-wide analysis of the family 10 plant pathogenesis-related proteins in Pyrus bretschneideri and functional analysis of PbrMLP for Colletotrichum fructicola resistance
Pathogenesis-related (PR) genes are key regulators of plant adaptation responses to biotic and abiotic stresses. Family 10 PRs (PR10s, also known as major latex proteins) are usually induced by pathogens and envi...
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Open AccessALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification
Previous studies have demonstrated the role of N6-methyladenosine (m6A) RNA methylation in various biological processes, our research is the first to elucidate its specific impact on LCAT mRNA stability and adipo...
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Open AccessA multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome
The human vagina harbours diverse microorganisms—bacteria, viruses and fungi—with profound implications for women’s health. Genome-level analysis of the vaginal microbiome across multiple kingdoms remains limi...
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Open AccessAssociation between indicators of visceral lipid accumulation and infertility: a cross-sectional study based on U.S. women
Evidence on the association between visceral lipid accumulation and infertility remains limited and controversial. Therefore, the current investigation is the first investigation to unveil this correlation by ...
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Open AccessIntegrated transcriptomic and metabolomic analysis provides insight into the pollen development of CMS-D1 rice
Cytoplasmic male sterility (CMS) has greatly improved the utilization of heterosis in crops due to the absence of functional male gametophyte. The newly developed sporophytic D1 type CMS (CMS-D1) rice exhibits...
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Open AccessN6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanisms for this ...
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Open AccessInhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Diabetic cardiomyopathy is characterized by myocardial lipid accumulation and cardiac dysfunction. Bile acid metabolism is known to play a crucial role in cardiovascular and metabolic diseases. Takeda G-protei...
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Open AccessCurrent applications of intestinal organoids: a review
In the past decade, intestinal organoid technology has paved the way for reproducing tissue or organ morphogenesis during intestinal physiological processes in vitro and studying the pathogenesis of various in...
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Open AccessComparison of allo-SCT, auto-SCT and chemotherapy for the treatment of patients with low- or intermediate-risk acute myeloid leukemia: a network meta-analysis
The therapeutic status of allogeneic stem cell transplantation (allo-SCT) as a post-remission treatment for patients with high-risk acute myeloid leukemia (AML) was well-accepted. However, the optimal treatmen...
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Open AccessLipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy
Hepatic stellate cells (HSCs) play a crucial role in the development of fibrosis in non-alcoholic fatty liver disease (NAFLD). Small extracellular vesicles (sEV) act as mediators for intercellular information ...
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Open AccessAlleles on locus chromosome 4B from different parents confer tiller number and the yield-associated traits in wheat
Pleiotropy is frequently detected in agronomic traits of wheat (Triticum aestivum). A locus on chromosome 4B, QTn/Ptn/Sl/Sns/Al/Tgw/Gl/Gw.caas-4B, proved to show pleiotropic effects on tiller, spike, and grain tr...
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Open AccessIn vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association ...
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Retraction Note: Vacuolar protein sorting 35 (VPS35) acts as a tumor promoter via facilitating cell cycle progression in pancreatic ductal adenocarcinoma
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Open AccessComparative analysis of POD genes and their expression under multiple hormones in Pyrus bretschenedri
Class III peroxidase (POD) enzymes play vital roles in plant development, hormone signaling, and stress responses. Despite extensive research on POD families in various plant species, the knowledge regarding t...
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Open AccessRetraction Note: Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy
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First report of mume-associated luteovirus (MaLV) in apricot in China
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Open AccessMetaDb: a database for metabolites and their regulation in plants with an emphasis on medicinal plants
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Open AccessDietary inflammatory impact on NAFLD development in obese vs. lean individuals: an analysis based on NHANES 2003–2018
Non-alcoholic fatty liver disease (NAFLD), often linked with obesity, can also affect individuals with normal weight, a condition known as “lean NAFLD”, imposing comparable burdens and adverse effects. However...
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Open AccessMed1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involv...
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Open AccessCircadian rhythm response and its effect on photosynthetic characteristics of the Lhcb family genes in tea plant
The circadian clock, also known as the circadian rhythm, is responsible for predicting daily and seasonal changes in the environment, and adjusting various physiological and developmental processes to the appr...
