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Article
Open AccessALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification
Previous studies have demonstrated the role of N6-methyladenosine (m6A) RNA methylation in various biological processes, our research is the first to elucidate its specific impact on LCAT mRNA stability and adipo...
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Article
Open AccessIncremental high average-utility itemset mining: survey and challenges
The High Average Utility Itemset Mining (HAUIM) technique, a variation of High Utility Itemset Mining (HUIM), uses the average utility of the itemsets. Historically, most HAUIM algorithms were designed for sta...
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Article
Open AccessStructural insights into the activation and inhibition of CXC chemokine receptor 3
The chemotaxis of CD4+ type 1 helper cells and CD8+ cytotoxic lymphocytes, guided by interferon-inducible CXC chemokine 9–11 (CXCL9–11) and CXC chemokine receptor 3 (CXCR3), plays a critical role in type 1 immuni...
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Article
Open AccessTertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer
Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in sha** the immune status of r...
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Article
Examining the Impact of Digital Economy on Environmental Sustainability in China: Insights into Carbon Emissions and Green Growth
In recent years, the global community has witnessed a growing awareness of the environmental challenges posed by climate change and the urgent need for sustainable development. As a significant player on the w...
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Article
Open AccessGLP-1(7–36) protected against oxidative damage and neuronal apoptosis in the hippocampal CA region after traumatic brain injury by regulating ERK5/CREB
Glucagon-like peptide-1 (GLP-1) (7–36) amide, an endogenous active form of GLP-1, has been shown to modulate oxidative stress and neuronal cell survival in various neurological diseases.
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Article
Open AccessImproved adaptive-phase fuzzy high utility pattern mining algorithm based on tree-list structure for intelligent decision systems
With the rapid development of AI and big data mining technologies, computerized medical decision-making has become increasingly prominent. The aim of high-utility pattern mining (HUPM) is to discover meaningfu...
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Article
Open AccessOutcome and characteristics of nonsecretory multiple myeloma compared with secretory multiple myeloma: a retrospective multicenter study from China
Nonsecretory multiple myeloma (NSMM) is a rare type of multiple myeloma (MM). Few studies have described the clinical features and outcomes of NSMM in novel agents. Additionally, the prognostic characteristics...
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Article
The antagonism and cohesion of the upstream supply chain under information asymmetry
Information asymmetry leads to short-term competitive antagonism between downstream manufacturers and upstream suppliers. This paper applies a master-slave game to reproduce the interest conflict between a man...
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Article
Bidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis
Epigenetic regulation has crucial implications for myocardial fibrosis. It has been reported that autophagy, regulated by miR-145, is implicated in the proliferation and fibrosis of cardiac fibroblasts (CFs). ...
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Article
Open AccessProof of crystal-field-perturbation-enhanced luminescence of lanthanide-doped nanocrystals through interstitial H+ do**
Crystal-field perturbation is theoretically the most direct and effective method of achieving highly efficient photoluminescence from trivalent lanthanide (Ln3+) ions through breaking the parity-forbidden nature ...
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Article
Boosting self-trapped exciton emission from Cs3Cu2I5 nanocrystals by do**-enhanced exciton-phonon coupling
Self-trapped excitons (STEs) emission from halide perovskites with strong exciton-phonon coupling has attracted considerable attention due to the widespread application in optoelectronic devices. Nevertheless,...
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Article
Acetic acid-mediated rapid cubic-to-hexagonal (α–β) phase transformation for ultra-bright lanthanide-doped β-NaYF4 nano-bioprobes
Hexagonal-phase NaYF4 (β-NaYF4) has been acknowledged to be one of the most efficient do** hosts to prepare bright lanthanide-doped luminescent nano-bioprobes for various biomedical applications. However, to da...
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Article
Open AccessHybrid design for sports data visualization using AI and big data analytics
In sports data analysis and visualization, understanding collective tactical behavior has become an integral part. Interactive and automatic data analysis is instrumental in making use of growing amounts of co...
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Article
Open AccessThe MODIFY Study Protocol: An Open-Label, Single-Arm, Multicenter, Prospective Pragmatic Study of Ixazomib-Based Triple-Drug Therapy in Chinese Patients with Multiple Myeloma
Although the bortezomib-based triple-drug therapy is considered as a front-line therapy for multiple myeloma (MM) in Chinese patients, increased level of toxicity leads to treatment dissatisfaction. Treatment ...
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Article
Open AccessOverexpressed cold inducible RNA-binding protein improves cell viability and EGF expression in glial cells
Cold inducible RNA-binding protein (CIRP) is a key protein in the hypothermic therapy. Highly expressed CIRP exerts a neuroprotective effect on neurons. The aim of this study is to provide the evidence of the ...
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Article
Open AccessHuman papillomavirus integration perspective in small cell cervical carcinoma
Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, we report human papillomavirus features and genomic landscape in SCCC via high-throughput HPV captured sequencing, whole-genome s...
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Article
Open AccessCutaneous metastasis of carcinomatous component of ovarian carcinosarcoma: A case report and review of the literature
Skin metastasis of ovarian cancer is extremely rare. We report an unusual case of ovarian carcinosarcoma with cutaneous metastasis of carcinomatous component that displayed distinct clinical manifestation. A 4...
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Article
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity
Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated processes and is highly associated with human diseases. Mechanism studies of the crosstalk have been of the central focus...
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Article
Open AccessRhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment
The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research has shown that the SJHY formula has significant anti-i...
