34,968 Result(s)
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Open AccessA high security coding and anti-counterfeiting method based on the nonlinear magnetization response of superparamagnetic nanomaterials
Traditional coding methods based on graphics and digital or magnetic labels have gradually decreased their anti-counterfeiting because of market popularity. This paper presents a new magnetic anti-counterfeiti...
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Open AccessNLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer
Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remain...
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Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Open AccessBiparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCS...
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Open AccessMulti-omic characterization of allele-specific regulatory variation in hybrid pigs
Hybrid map** is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai...
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Open AccessMagnetic excitations in strained infinite-layer nickelate PrNiO2 films
Strongly correlated materials respond sensitively to external perturbations such as strain, pressure, and do**. In the recently discovered superconducting infinite-layer nickelates, the superconducting trans...
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Open AccessAccelerating Formulation Design via Machine Learning: Generating a High-throughput Shampoo Formulations Dataset
Liquid formulations are ubiquitous yet have lengthy product development cycles owing to the complex physical interactions between ingredients making it difficult to tune formulations to customer-defined proper...
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Open AccessSpatial distribution of metabolites in processing Ziziphi Spinosae Semen as revealed by matrix-assisted laser desorption/ionization mass spectrometry imaging
Ziziphi Spinosae Semen (ZSS) is the first choice for the treatment of insomnia. This research aimed to reveal the spatial distribution of identifying quality markers of ZSS and to illustrate the metabolite qualit...
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Open AccessIdentification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and a leading cause of neurological disability in young adults. Clinical presentation and disease course are highly heterog...
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Open AccessNumerical study on the stimulation effect of boundary sealing and hot water injection in marine challenging gas hydrate extraction
This study proposed a novel development mode combining boundary sealing and hot water injection to address the challenges of gas leakage, limited reservoir sensible heat, boundary water intrusion, and low prod...
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Open AccessMiddle and Late Pleistocene Denisovan subsistence at Baishiya Karst Cave
Genetic and fragmented palaeoanthropological data suggest that Denisovans were once widely distributed across eastern Eurasia1–3. Despite limited archaeological evidence, this indicates that Denisovans were capab...
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Open AccessA(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pan...
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Open AccessDynamics of polarization-tuned mirror symmetry breaking in a rotationally symmetric system
Lateral momentum conservation is typically kept in a non-absorptive rotationally symmetric system through mirror symmetry via Noether’s theorem when illuminated by a homogeneous light wave. Therefore, it is st...
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Open AccessDCAF15 control of cohesin dynamics sustains acute myeloid leukemia
The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological fu...
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Open AccessAnalysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats
Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic stimuli in culture, whic...
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Open AccessNBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...
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Open AccessCharacterization of the GGP gene family in potato (Solanum tuberosum L.) and Pepper (Capsicum annuum L.) and its expression analysis under hormonal and abiotic stresses
GDP-l-galactose phosphorylase (GGP) is a key rate-limiting enzyme in plant ascorbic acid synthesis, which plays an important role in plant growth and development as well as stress response. However, the presence ...
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Open AccessThe impact of intellectual property demonstration policies on carbon emission efficiency
Confronted with the concurrent challenges of economic advancement and environmental management, this study explores whether implementing Intellectual Property Demonstration Policies (IPDP) can be a covert forc...
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Open AccessActivation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η
This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its related mechanisms. ...
