UV-A
Biological Effects of Ultraviolet Radiation with Emphasis on Human Responses to Longwave Ultraviolet
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Open AccessAnalysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats
Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic stimuli in culture, whic...
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Open AccessSelective reduction of visceral adipose tissue with injectable ice slurry
Reduction in visceral adipose tissue (VAT) mass reduces body weight and metabolic disease risk in obese patients. However surgical removal of VAT is highly invasive and thus not clinically feasible. We develop...
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Open AccessFast-acting and injectable cryoneurolysis device
Cryoneurolysis is an opioid-sparing therapy for long-lasting and reversible reduction of pain. We developed a nerve-selective method for cryoneurolysis by local injection of ice-slurry (− 5 to − 6 °C) that ind...
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Open AccessMulti-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns
Impaired wound healing is an immense medical challenge, and while autologous skin grafting remains the “gold-standard” therapeutic option for repairing wounds that cannot be closed by primary or secondary inte...
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Injectable slurry for selective destruction of neck adipose tissue in New Zealand obese mouse model
Increased neck circumference is a major risk factor for obstructive sleep apnea (OSA). New data suggest that increased adipose tissue in the neck may be a contributory cause of OSA. The aim of this study was t...
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Research and Future Directions
In this chapter, an overview of new research and emerging technologies is provided. The subject is inherently speculative and the clinical adoption of these technologies is far from certain. Notwithstanding th...
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An elastic second skin
We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that ca...
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A micro-sterile inflammation array as an adjuvant for influenza vaccines
There is an urgent need of adjuvants for cutaneous vaccination. Here, we report that micro-sterile inflammation induced at inoculation sites can augment immune responses to influenza vaccines in animal models....
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Animal models for nickel allergy
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Nanoparticles reduce nickel allergy by capturing metal ions
Approximately 10% of the population in the USA1,2 suffer from nickel allergy3,4,5, and many are unable to wear jewellery or handle coins and other objects that contain nickel6,7,8,9,10. Many agents have been deve...
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Summary and Future
Decades of effort understanding, inventing, designing, develo** and using photothermal treatments for human disease have clearly improved medical care. Lasers are the treatment of choice for common eye, skin...
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Open AccessTransdermal microconduits by microscission for drug delivery and sample acquisition
Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum ...
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Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment
Clinical trials of topical ALA in photodynamic therapy (PDT) of basal cell carcinoma (BCC) show significant recurrence rates. Exogenous 5-aminolevulinic acid (ALA) is converted by intracellular enzymes to phot...
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Improved criteria for the recognition of atherosclerotic plaque using fluorescence spectroscopy
To determine the fluorescence pattern for distinguishing normal (N) from calcified and fibrous plaque (P), fluorescence spectra of cadaveric aorta were measured with a spectrofluorometer. Emission (Em) and exc...
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Lasers in Dermatology
Dermatology has been at the forefront of photomedicine, and has fostered great interest in medical laser applications. In the decade following invention of the ruby laser, this device was used to experimentall...
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Laser Reflectance Spectroscopy of Tissue
The optics of living tissue are complicated by gross and microscopic inhomogeneous structure, dynamic changes in blood content, shape, multiple absorbing compounds, and extreme local and individual variations....
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Optical studies of pulsed-laser fragmentation of biliary calculi
The fragmentation of gallstones and kidney stones using pulsed visible laser radiation has recently been demonstrated; however, the fragmentation mechanism is not well understood. The temporal and spectral cha...
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Experimental Techniques in Photoimmunology
Exposing an experimental sample to nonionizing radiation is similar in some ways to adding a chemical reagent to the sample, except that photons instead of molecules are being added. Just as interpretation of ...
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Tissue Optics and Photoimmunology
Whenever an organism, organ, or cell is exposed to UV or other optical radiation, the response, or lack of response, depends to some extent on the optical properties of the exposed tissues. Delineating the exa...
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