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An anti-CRISPR that pulls apart a CRISPR–Cas complex

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  1. Article

    Open Access

    Reducing nonradiative recombination for highly efficient inverted perovskite solar cells via a synergistic bimolecular interface

    Reducing interface nonradiative recombination is important for realizing highly efficient perovskite solar cells. In this work, we develop a synergistic bimolecular interlayer (SBI) strategy via 4-methoxypheny...

    Shaobing **ong, Fuyu Tian, Feng Wang, Ai** Cao, Zeng Chen in Nature Communications (2024)

  2. Article

    Open Access

    Comprehensive application of AI algorithms with TCR NGS data for glioma diagnosis

    T-cell receptor (TCR) detection can examine the extent of T-cell immune responses. Therefore, the article analyzed characteristic data of glioma obtained by DNA-based TCR high-throughput sequencing, to predict...

    Kaiyue Zhou, Zhengliang **ao, Qi Liu, Xu Wang, Jiaxin Huo, **aoqi Wu in Scientific Reports (2024)

  3. Article

    Open Access

    High levels of high-density lipoprotein cholesterol may increase the risk of diabetic kidney disease in patients with type 2 diabetes

    Studies have indicated that low high-density lipoprotein cholesterol (HDL-C) level is an important risk factor for diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D). However, whether higher ...

    Huabin Wang, Junqi Wu, Meili Lin, Yifei Hu, Yongjun Ma in Scientific Reports (2024)

  4. Article

    Open Access

    Effects of low-intensity pulsed ultrasound on the microorganisms of expressed prostatic secretion in patients with IIIB prostatitis

    To detect and analyze the changes of microorganisms in expressed prostatic secretion (EPS) of patients with IIIB prostatitis before and after low-intensity pulsed ultrasound (LIPUS) treatment, and to explore t...

    Wei-Jie Song, Ji-Wei Huang, Yuan Liu, Jie Wang, Wei Ding in Scientific Reports (2024)

  5. Article

    Open Access

    A high security coding and anti-counterfeiting method based on the nonlinear magnetization response of superparamagnetic nanomaterials

    Traditional coding methods based on graphics and digital or magnetic labels have gradually decreased their anti-counterfeiting because of market popularity. This paper presents a new magnetic anti-counterfeiti...

    Shi Bai, Yuxi Lin, **aoju Wang, **aodan Zhang, Takashi Yoshida in Scientific Reports (2024)

  6. Article

    Open Access

    NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer

    Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remain...

    Lin Ling, Jiahua Chen, Lei Zhan, Juanjuan Fu, Runhua He, Wenyan Wang in Scientific Reports (2024)

  7. Article

    Open Access

    Experimental study on the mechanical characteristics of weakly cemented mudstone under different loading rates

    With the gradual shift of coal mining to the western coal mining region of China, floor heave in weakly cemented mudstone roadways has become an issue affecting the safety and efficiency of coal mine productio...

    Junpeng Zou, Gang Li, Zibo Li, Yabing Zhang, Hang Liu, Yiming Wang in Scientific Reports (2024)

  8. Article

    Open Access

    KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2

    Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...

    Shilei Bi, Lijun Huang, Yongjie Chen, Zhenhua Hu, Shanze Li in Nature Communications (2024)

  9. Article

    Open Access

    Author Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice

    Tao Zhuang, Mei-Hua Chen, Ruo-** Wu, **g Wang, **-De Hu in Nature Communications (2024)

  10. Article

    Open Access

    Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells

    Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCS...

    **nyang Li, Wei Zhang, Yu Shu, Rui Huo, Chengyang Zheng, Qi Qi in Scientific Reports (2024)

  11. Article

    Open Access

    Multi-omic characterization of allele-specific regulatory variation in hybrid pigs

    Hybrid map** is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai...

    Jian** Quan, Ming Yang, **ngwang Wang, Gengyuan Cai in Nature Communications (2024)

  12. Article

    Open Access

    Magnetic excitations in strained infinite-layer nickelate PrNiO2 films

    Strongly correlated materials respond sensitively to external perturbations such as strain, pressure, and do**. In the recently discovered superconducting infinite-layer nickelates, the superconducting trans...

    Qiang Gao, Shiyu Fan, Qisi Wang, Jiarui Li, in Nature Communications (2024)

  13. Article

    Open Access

    Accelerating Formulation Design via Machine Learning: Generating a High-throughput Shampoo Formulations Dataset

    Liquid formulations are ubiquitous yet have lengthy product development cycles owing to the complex physical interactions between ingredients making it difficult to tune formulations to customer-defined proper...

    Aniket Chitre, Robert C. M. Querimit, Simon D. Rihm, Dogancan Karan in Scientific Data (2024)

  14. Article

    Open Access

    Spatial distribution of metabolites in processing Ziziphi Spinosae Semen as revealed by matrix-assisted laser desorption/ionization mass spectrometry imaging

    Ziziphi Spinosae Semen (ZSS) is the first choice for the treatment of insomnia. This research aimed to reveal the spatial distribution of identifying quality markers of ZSS and to illustrate the metabolite qualit...

    Donglai Ma, Mengwei Zhao, Haochuan Guo, Lili Wang, Yage Li in Scientific Reports (2024)

  15. Article

    Open Access

    Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis

    Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and a leading cause of neurological disability in young adults. Clinical presentation and disease course are highly heterog...

    Theresa L. Montgomery, Qin Wang, Ali Mirza, Deanna Dwyer, Qi Wu in Scientific Reports (2024)

  16. Article

    Open Access

    Numerical study on the stimulation effect of boundary sealing and hot water injection in marine challenging gas hydrate extraction

    This study proposed a novel development mode combining boundary sealing and hot water injection to address the challenges of gas leakage, limited reservoir sensible heat, boundary water intrusion, and low prod...

    Shuaishuai Nie, Ke Liu, Kangtai Xu, ** Zhong, Shixing Tang in Scientific Reports (2024)

  17. Article

    Open Access

    Middle and Late Pleistocene Denisovan subsistence at Baishiya Karst Cave

    Genetic and fragmented palaeoanthropological data suggest that Denisovans were once widely distributed across eastern Eurasia13. Despite limited archaeological evidence, this indicates that Denisovans were capab...

    Huan **a, Dongju Zhang, Jian Wang, Zandra Fagernäs, Ting Li, Yuanxin Li in Nature (2024)

  18. Article

    Open Access

    A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases

    Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pan...

    Zaolan Liang, **a Lin, Lihong Sun, Kimberly M. Edwards in Nature Communications (2024)

  19. Article

    Open Access

    Dynamics of polarization-tuned mirror symmetry breaking in a rotationally symmetric system

    Lateral momentum conservation is typically kept in a non-absorptive rotationally symmetric system through mirror symmetry via Noether’s theorem when illuminated by a homogeneous light wave. Therefore, it is st...

    Yu Zhang, Zhibin Li, Zhen Che, Wang Zhang, Yusen Zhang, Ziqi Lin in Nature Communications (2024)

  20. Article

    Open Access

    DCAF15 control of cohesin dynamics sustains acute myeloid leukemia

    The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological fu...

    Grant P. Grothusen, Renxu Chang, Zhendong Cao, Nan Zhou in Nature Communications (2024)

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