4 Result(s)
within
**guang Zang
Oncology
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Article
Open AccessAn organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers
Salivary gland tumors (SGTs) include a large group of rare neoplasms in the head and neck region, and the heterogeneous and overlap** features among the subtypes frequently make diagnostic difficulties. Ther...
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Article
Open AccessPKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model
Prostate cancer disseminates primarily into the adjacent lymph nodes, which is related to a poor outcome. Atypical protein kinase C ζ (PKCζ) is highly expressed in aggressive prostate cancer and correlates wit...
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Article
Open AccessVascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts
Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastas...
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Article
Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency
Vascular endothelial growth factor (VEGF)-A regulates angiogenesis, vascular morphology and permeability by signaling through its receptor VEGFR-2. The Shb adapter protein has previously been found to relay certa...
