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Article
Open AccessAuthor Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessPublisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization
The original version of this Article contained errors in Figures 1, 3 and 4. In panels b and d of Figure 1, the labels ‘Sdc4-/-’ were inadvertently replaced by ‘Sdc4+/+‘. In panels c and d of Figure 3, the labels...
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Article
Open AccessN-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization
The proteoglycan Syndecan-2 (Sdc2) has been implicated in regulation of cytoskeleton organization, integrin signaling and developmental angiogenesis in zebrafish. Here we report that mice with global and induc...
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Article
Restoration of brain circulation and cellular functions hours post-mortem
The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular an...
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Article
Open AccessSUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Regulation of VEGFR2 represents an important mechanism for the control of angiogenesis. VEGFR2 activity can be regulated by post-translational modifications such as ubiquitination and acetylation. However, whe...
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Article
Open AccessHyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or therapeutic agent is available. Here we ...
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Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency
Vascular endothelial growth factor (VEGF)-A regulates angiogenesis, vascular morphology and permeability by signaling through its receptor VEGFR-2. The Shb adapter protein has previously been found to relay certa...
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Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
The cellular oxygen-sensing enyzme PHD2 uses oxygen to degrade hypoxia-inducible factor 1α. Using a mouse model of limb ischaemia, Takeda et al. link oxygen sensing through PHD2 to macrophage phenotype and arteri...
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Chapter and Conference Paper
Vessel Connectivity Using Murray’s Hypothesis
We describe a new method for vascular image analysis that incorporates a generic physiological principle to estimate vessel connectivity, which is a key issue in reconstructing complete vascular trees from ima...
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Open AccessMicro computed tomography for vascular exploration
Vascular exploration of small animals requires imaging hardware with a very high spatial resolution, capable of differentiating large as well as small vessels, in both in vivo and ex vivo studies. Micro Computed ...
