-
Article
Welding of additive manufacturing AlSi10Mg alloys using a laser metal deposition process with different heat inputs
Welding of AlSi10Mg alloys fabricated by additive manufacturing (AM) has been recently conducted to meet the demands for joining or repairing them. However, high susceptibility to porosity occurring in weld me...
-
Article
Evaluation of fragility fracture risk using deep learning based on ultrasound radio frequency signal
It was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality, and economic burden associated with fragility fracture. The quantitat...
-
Article
Open AccessNew mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling
Osteoporosis is a global health issue characterized by decreased bone mass and microstructural degradation, leading to an increased risk of fractures. This study aims to explore the molecular mechanism by whic...
-
Article
Open AccessThreshold of hyperglycaemia associated with mortality in critically ill patients: a multicentre, prospective, observational study using continuous glucose monitoring
Continuous glucose monitoring (CGM) provides comprehensive information on the exposure to dysglycaemia. This study aimed to investigate the threshold of hyperglycaemia related to mortality risk in critically i...
-
Article
Open AccessBasement membrane-related MMP14 predicts poor prognosis and response to immunotherapy in bladder cancer
Basement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of tumor cells. However, few biomarkers based on BM have been developed ...
-
Article
Hierarchical cobalt-molybdenum layered double hydroxide arrays power efficient oxygen evolution reaction
Transition metal-based layered double hydroxides (LDHs) have been capable of working efficiently as catalysts in the basic oxygen evolution reaction (OER) for sustaining hydrogen production of alkaline water e...
-
Article
Open AccessStructural deviations of the posterior fossa and the cerebellum and their cognitive links in a neurodevelopmental deletion syndrome
High-impact genetic variants associated with neurodevelopmental disorders provide biologically-defined entry points for mechanistic investigation. The 3q29 deletion (3q29Del) is one such variant, conferring a ...
-
Article
Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy
Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of major genetic variants in the etiology of CP, we conducted exome sequencing on a large-scale cohort with clinical m...
-
Article
Open AccessA membrane associated tandem kinase from wild emmer wheat confers broad-spectrum resistance to powdery mildew
Crop wild relatives offer natural variations of disease resistance for crop improvement. Here, we report the isolation of broad-spectrum powdery mildew resistance gene Pm36, originated from wild emmer wheat, that...
-
Article
Phenolic resin derivatized TiO2-walnut shell carbon hybrid materials for solar photocatalytic phenol removal
As a toxic organic pollutant in industrial wastewaters, phenol wastewater treatment is investigated extensively. TiO2 based photocatalysts are widely used for such applications, due to its ecofriendly properties,...
-
Article
Lipopolysaccharide-Educated Cancer-Associated Fibroblasts Facilitate Malignant Progression of Ovarian Cancer Cells via the NF-kB/IL-6/JAK2 Signal Transduction
Gram-negative bacteria increase in ovarian cancer (OC) tissues, but its association with OC progression remains largely unknown. The present study aimed to investigate whether and how cancer-associated fibrobl...
-
Article
First Record of Cyclocarya from the Early Oligocene Qaidam Basin, North Tibet: Implications for the Paleogeography and Paleoecology
As the largest intermontane basin in the northeastern Tibetan Plateau (TP), the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the TP. In t...
-
Article
Evaluation of tumor microvasculature with 3D ultrasound localization microscopy based on 2D matrix array
Evaluation of tumor microvascular morphology is of great significance in tumor diagnosis, therapeutic effect prediction, and surgical planning. Recently, two-dimensional ultrasound localization microscopy (2DU...
-
Article
Open AccessCorrection: NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
-
Chapter and Conference Paper
Reinforcement Learning-Based Streaming Process Discovery Under Concept Drift
Streaming process discovery aims to discover a process model that may change over time, co** with the challenges of concept drift in business processes. Existing studies update process models with fixed stra...
-
Chapter and Conference Paper
Co-designing Human–Chatbot Interaction for Various Healthcare Purposes: Considering Chatbots’ Social Characteristics and Communication Modalities
The last decade has witnessed the blooming growth of healthcare chatbots in behavior interventions, elderly care, healthcare education, online diagnosis, and elsewhere. To meet the users’ expectations and pref...
-
Chapter and Conference Paper
Development and Evaluation of Embodied Metaphors for Exergame Design: Considering Older Adults’ Bodily Experiences and Individual Perceptions
Exergames are suggested to improve older adults’ adherence to physical activity (PA) and thus greatly benefit their physical functions and well-being. Considering that older adults can face great challenges wh...
-
Chapter and Conference Paper
Exploring User Preferences and Acceptance of Digital Art Therapy Among Older Chinese Adults with Mild Cognitive Impairment
Mild cognitive impairment (MCI) occurs between the stages of normal aging and dementia and has a high possibility of progressing to Alzheimer’s disease. Early and effective intervention or treatment is essenti...
-
Article
Open AccessNOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages. While macrophages play a pivotal role in the in...
-
Article
Open AccessImproving enteral nutrition tolerance and protein intake maybe beneficial to intensive care unit patients
Enteral nutrition (EN) is important for critically ill patients. This study investigated the current situation of EN treatment in SHANGHAI intensive care units (ICUs). We hypothesized that improving EN practic...
