24 Result(s)

Article

Development and validation of an inflammatory biomarkers model to predict gastric cancer prognosis: a multi-center cohort study in China

Inflammatory factors have increasingly become a more cost-effective prognostic indicator for gastric cancer (GC). The goal of this study was to develop a prognostic score system for gastric cancer patients bas...

Shaobo Zhang, Hongxia Xu, Wei Li, Jiuwei Cui, Qingchuan Zhao, Zengqing Guo… in BMC Cancer (2024)

Article

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved trea...

Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena… in Communications Medicine (2024)

Article

Detection of mild cognitive impairment in Parkinson’s disease using gradient boosting decision tree models based on multilevel DTI indices

Cognitive dysfunction is the most common non-motor symptom in Parkinson’s disease (PD), and timely detection of a slight cognitive decline is crucial for early treatment and prevention of dementia. This study ...

Boyu Chen, Ming Xu, Hongmei Yu, Jiachuan He… in Journal of Translational Medicine (2023)

Article

Status quo of the public’s knowledge of probiotics based on video-sharing platforms

Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regard...

Chun-Hui Jiang, Jia-Jia Xu, Chao Xu, Shi-Yue Chen, Jia-Yun Chen… in BMC Public Health (2023)

Article

Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers. The growing interest in this ar...

Rexiati Ruze, Jianlu Song, **npeng Yin… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Noninvasive prediction of axillary lymph node status in breast cancer using promoter profiling of circulating cell-free DNA

Lymph node metastasis (LNM) is one of the most important factors affecting the prognosis of breast cancer. The accurate evaluation of lymph node status is useful to predict the outcomes of patients and guide t...

Zhi-Wei Guo, Qing Liu, Xu Yang, Geng-** Cai… in Journal of Translational Medicine (2022)

Article

Spatiotemporal trends and ecological determinants of cardiovascular mortality among 2844 counties in mainland China, 2006–2020: a Bayesian modeling study of national mortality registries

Cardiovascular disease (CVD) is the leading cause of death in China. No previous study has reported CVD mortality at county-level, and little was known about the nonmedical ecological factors of CVD mortality ...

Wei Wang, Junming Li, Yunning Liu, Pengpeng Ye, Chengdong Xu, Peng Yin… in BMC Medicine (2022)

Article

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype

Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the understanding of non-genetic variation provides a new perspective to study the heterogenei...

Xuming Song, Te Zhang, Hanlin Ding, Yipeng Feng, Wenmin Yang, Xuewen Yin… in Oncogenesis (2022)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

Radiomic analysis for predicting prognosis of colorectal cancer from preoperative ¹⁸F-FDG PET/CT

To develop and validate a survival model with clinico-biological features and ¹⁸F- FDG PET/CT radiomic features via machine learning, and for predicting the prognosis from the primary tumor of colorectal cancer.

Lilang Lv, Bowen **n, Yichao Hao, Ziyi Yang, Junyan Xu… in Journal of Translational Medicine (2022)

Article

Disrupted intrinsic functional brain topology in patients with major depressive disorder

Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...

Hong Yang, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Molecular Psychiatry (2021)

Article

Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma

Lu Han, Ji-Shuai Zhang, Jian Zhou, Ke-Shu Zhou, Ben-Ling Xu, Lin-Lin Li… in Leukemia (2021)

Article

Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-termi...

**ao Fang, Song’en Xu, Yiyue Zhang, ** Xu, Zhibin Huang, Wei Liu… in Leukemia (2021)

Article

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interv...

**aofen Ruan, Yi** Li, Yuanlong Sun, Meijun Jia, **aowen Xu, Li Huo, Wei Song… in Trials (2021)

Article

C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer

PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency in HR-proficient cancers...

Jiahong Tan, Xu Zheng, Mengchen Li, Fei Ye, Chunyan Song, Cheng Xu… in Oncogene (2021)

Article

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the A...

Jun Wang, Bin-Lu Sun, Yang **ang, Ding-Yuan Tian, Chi Zhu… in Translational Psychiatry (2020)

Article

Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples

COVID-19 (coronavirus disease 2019) has caused a major epidemic worldwide; however, much is yet to be known about the epidemiology and evolution of the virus partly due to the scarcity of full-length SARS-CoV-...

Minfeng **ao, **aoqing Liu, **gkai Ji, Min Li, Jiandong Li, Lin Yang… in Genome Medicine (2020)

Article

Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study

Laparoscopic surgery, fast-track perioperative treatment and XELOX chemotherapy are effective strategies for shortening the duration of hospital stay for cancer patients. This trial aimed to clarify the safety...

Jun Li, **ang-**ng Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang… in BMC Cancer (2019)

Article

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng… in Journal of Translational Medicine (2017)