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Article
Rhenium-boosted electrocatalytic activity and durability of pyrolytic IrO2 for acidic oxygen evolution
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Article
Open AccessSafety and efficacy of tract embolization using gelatin sponge particles in reducing pneumothorax after CT-guided percutaneous lung biopsy in patients with emphysema
The incidence of pneumothorax is higher in patients with emphysema who undergo percutaneous lung biopsy. Needle embolization has been shown to reduce the incidence of pneumothorax in patients with emphysema. E...
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Article
The SLEGS beamline of SSRF
The Shanghai Laser Electron Gamma Source (SLEGS, located in BL03SSID) beamline at the Shanghai Synchrotron Radiation Facility (SSRF) is a Laser Compton Scattering (LCS) gamma source used for the investigation ...
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Article
Open AccessTRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription
The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1s and cDC2s), is controlled by specific transcription factors. IRF8 is essential for th...
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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis
To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.
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Article
Open AccesscGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer
Cancer cells frequently evolve necroptotic resistance to overcome various survival stress during tumorigenesis. However, we have previously showed that necroptosis is widespread in head and neck squamous cell ...
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Open AccessIntestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation
Variations exist in the response of patients with Crohn’s disease (CD) to ustekinumab (UST) treatment, but the underlying cause remains unknown. Our objective was to investigate the involvement of immune cells...
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Article
Open AccessA novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension
Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...
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Article
Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment
The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic unresolved inflammation and overproduction of reactive oxygen species (ROS) being major drivers of plaque progression. Nan...
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Open AccessAcetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a c...
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Article
Open AccessLocalization of scalar field on the brane-world by coupling with gravity
In this paper, we consider a coupling mechanism between the kinetic term and the gravity, in which a coupling function F (R) is introduced into the kinetic term of the five-dimensional scalar field. Based on this...
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Article
Open AccessCarbenoid-involved reactions integrated with scaffold-based screening generates a Nav1.7 inhibitor
The discovery of selective Nav1.7 inhibitors is a promising approach for develo** anti-nociceptive drugs. In this study, we present a novel oxindole-based readily accessible library (OREAL), which is charact...
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Open AccessIntegrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer
Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.
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Article
Open AccessLB-BMBC: MHBiaffine-CNN to Capture Span Scores with BERT Injected with Lexical Information for Chinese NER
A substantial body of research has shown that introducing lexical information in Chinese Named Entity Recognition (NER) tasks can enhance the semantic and boundary information of Chinese words. However, in mos...
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Open AccessDifferential reinforcement of cGAS-STING pathway-involved immunotherapy by biomineralized bacterial outer membrane-sensitized EBRT and RNT
Radiotherapy (RT), including external beam radiation therapy (EBRT) and radionuclide therapy (RNT), realizes physical killing of local tumors and activates systemic anti-tumor immunity. However, these effects ...
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Article
Collective Movement Simulation: Methods and Applications
Collective movement simulations are challenging and important in many areas, including life science, mathematics, physics, information science and public safety. In this survey, we provide a comprehensive revi...
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Article
Open AccessStructural basis for human Cav3.2 inhibition by selective antagonists
The Cav3.2 subtype of T-type calcium channels has been targeted for develo** analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM structures of Cav3.2 alone and in compl...
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Article
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation
Lipid droplet tethering with mitochondria for fatty acid oxidation is critical for tumor cells to counteract energy stress. However, the underlying mechanism remains unclear. Here, we demonstrate that glucose ...
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Article
Open AccessEvaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Human liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the ...
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Article
Open AccessGenomic analyses reveal the stepwise domestication and genetic mechanism of curd biogenesis in cauliflower
Cauliflower (Brassica oleracea L. var. botrytis) is a distinctive vegetable that supplies a nutrient-rich edible inflorescence meristem for the human diet. However, the genomic bases of its selective breeding hav...
