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Article
Open AccessPodocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury
Recent studies have shown the crucial role of podocyte injury in the development of diabetic kidney disease (DKD). Deubiquitinating modification of proteins is widely involved in the occurrence and development...
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Article
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation
Lipid droplet tethering with mitochondria for fatty acid oxidation is critical for tumor cells to counteract energy stress. However, the underlying mechanism remains unclear. Here, we demonstrate that glucose ...
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Article
Open AccessCardiovascular health and life expectancy with and without cardiovascular disease in the middle-aged and elderly Chinese population
High cardiovascular health (CVH) was associated with lower risk of cardiovascular disease (CVD) and longer life expectancy. However, whether life years lived without CVD could increase faster than or at least ...
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Article
The effect of adverse pregnancy outcomes on vascular aging in young women: the Kailuan study
Adverse pregnancy outcomes (APOs) are at increased future cardiovascular risk and require effective risk mitigation. However, data regarding appropriate postpartum screening for young women with APOs are lacki...
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Article
Open AccessAssociation of the time course of Chinese visceral adiposity index accumulation with cardiovascular events in patients with hypertension
The Chinese visceral adiposity index (CVAI), a simple surrogate measure of visceral fat, is significantly associated with cardiovascular disease (CVD) risk in the general population. This study aimed to evalua...
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Article
Repurposing FBP1: dephosphorylating IκBα to suppress NFκB
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Cloud-native-based flexible value generation mechanism of public health platform using machine learning
Public health machinery learning platform based on cloud-native is a system platform that combines machine learning frameworks and cloud-native technology for public health services. The problem of how its fle...
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Article
Open AccessInhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against CDK2 are ATP competitors that are ...
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Article
Post-transplant cyclophosphamide versus antithymocyte globulin in allogeneic hematopoietic cell transplantation: a meta-analysis
Graft-versus-host disease (GVHD) prophylaxis based on post-transplant cyclophosphamide (PTCy) or antithymocyte globulin (ATG) is widely used in allogeneic hematopoietic stem cell transplantations (allo-HCT). T...
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Article
Role of Vitamin D in Patients with Heart Failure with Reduced Ejection Fraction
Heart failure (HF) with reduced ejection fraction (HFrEF) presents as the severest phenotype on the spectrum of HF. Although great progress has been made with respect to its treatment over the past 3 decades, ...
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Article
Development of a multiplex TaqMan real-time RT-PCR assay for simultaneous detection of Asian prunus viruses, plum bark necrosis stem pitting associated virus, and peach latent mosaic viroid
Asian prunus viruses (APV 1, APV 2 and APV 3), Plum bark necrosis stem pitting associated virus (PBNSPaV) and Peach latent mosaic viroid (PLMVd) are pathogens that infect Prunus species. A single-tube multiplex, ...
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Article
One-step multiplex RT-PCR for simultaneous detection of four pome tree viroids
Apple scar skin viroid (ASSVd), Apple dimple fruit viroid (ADFVd), Apple fruit crinkle viroid (AFCVd), and Pear blister canker viroid (PBCVd) infect pome fruit trees. These viroids are important ...
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Article
Integrated approach to the problem of pharmaceutical products in the environment: an overview
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Article
A procedure for comparing the reactivity of different hydrocarbons in cracking over zeolites
The cracking of hydrocarbons over zeolites is accompanied by a significant production of coke, which causes their rapid deactivation. The coking and deactivation rates depend very much on the reactant. This ma...
