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Article
Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Article
Remarkable mechanical performance at low temperatures of hydroxy-terminated polybutadiene enhanced by hyperbranched polysiloxane
The inadequate mechanical properties and limited low temperature adaptability of Hydroxy-terminated polybutadiene (HTPB) impose constraints on its practical utilization in solid propellant applications. In the...
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Article
Characterization of whole genomes from recently emerging Mpox cases in several regions of China, 2023
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Article
Unveiling the role of HIST2H2AC in stroke through single-cell and transcriptome analysis
Stroke is a leading cause of death and disability, and genetic risk factors play a significant role in its development. Unfortunately, effective therapies for stroke are currently limited. Early detection and ...
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Article
Cause, Stability Analysis, and Monitoring of Cracks in the Gate Storehouse of a Flood Diversion Sluice
The cracks in a gate storehouse for a flood-diversion sluice of the Wangfuzhou Water Conservancy Project were studied to diagnose the structural safety. The study was based on an integrated method that involve...
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Article
Association of molecular subtypes and treatment with survival in invasive micropapillary breast cancer: an analysis of the Surveillance, Epidemiology, and End Results database
This study aims to examine the features, treatments, and survival of invasive micropapillary carcinoma (IMPC) according to different molecular subtypes.
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Article
Open AccessFibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening disease without an effective drug at present. Fibroblast growth factor 21 (FGF21) was reported to be protective against ...
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Article
Open AccessGinseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment
Lines of evidence indicated that, immune checkpoints (ICs) inhibitors enhanced T cell immune response to exert anti-tumor effects. However, T cell exhaustion has been so far a major obstacle to antitumor immun...
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Article
Open AccessProteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways
Post-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE). Lysine 2-hydroxyisobutyryl (Khib), as an emerging post-translational ...
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Article
A nomogram for distinguishing benign and malignant parotid gland tumors using clinical data and preoperative blood markers: development and validation
This study aimed to construct and validate a nomogram that incorporated clinical data and preoperative blood markers to differentiate BPGTs from MPGTs more efficiently and at low cost.
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Article
Open AccessAn IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants
Many of the currently available COVID-19 vaccines and therapeutics are not effective against newly emerged SARS-CoV-2 variants. Here, we developed the metallo-enzyme domain of angiotensin converting enzyme 2 (...
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Article
Open AccessGold nanoparticles combat enveloped RNA virus by affecting organelle dynamics
Enveloped RNA viruses are a group of viruses with an outer membrane derived from a host cell and a genome consisting of ribonucleic acid (RNA). These viruses rely on host cell machinery and organelles to repli...
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Article
MXene/AC Composite Membranes as an Electrode Material for Flexible Supercapacitors with Excellent Properties
In recent years, activated carbon materials have been widely used as electrode materials in supercapacitors due to their excellent electrical conductivity, huge specific surface area and chemical stability. A ...
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Article
Open AccessNeutralizing antibody levels associated with injectable and aerosolized Ad5-nCoV boosters and BA.2 infection
Several COVID-19 vaccines are in widespread use in China. Few data exist on comparative immunogenicity of different COVID-19 vaccines given as booster doses. We aimed to assess neutralizing antibody levels rai...
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Article
Open AccessThe crescent-like Golgi ribbon is shaped by the Ajuba/PRMT5/Aurora-A complex-modified HURP
Golgi apparatus (GA) is assembled as a crescent-like ribbon in mammalian cells under immunofluorescence microscope without knowing the sha** mechanisms. It is estimated that roughly 1/5 of the genes encodin...
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Article
Open AccessAnalyze of factors and prognosis of eyes lost to follow-up in retinal vein occlusive disease patients receiving anti-vascular endothelial growth factor therapy
Patients with macular edema (ME) secondary to retinal vein occlusion (RVO) who received at least one intravitreal injection of anti-vascular endothelial growth factor therapy (VEGF) and lost to follow-up (LTFU...
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Article
Open AccessAcupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p
The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been sho...
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Article
The effect of early-age freeze–thaw cycle damage on hydraulic concrete self-healing
The freeze–thaw cycle-damage test was designed and conducted on early-age hydraulic concrete at three freeze–thaw-damage ages (1 d, 2 d, 3 d) and two freeze–thaw cycles (5, 10). The compressive strength growth...
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Article
Open AccessCorrection: Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway
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Open AccessThe emerging role of the piRNA/PIWI complex in respiratory tract diseases
PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18–33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a...
