19 Result(s)
within
**ao-fei Lu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Open AccessHealthy eating index-2015 and its association with the prevalence of stroke among US adults
This study aims to investigate the relationship between the healthy eating index (HEI) and the prevalence of stroke within a diverse United States population. Employing a cross-sectional design, we utilized da...
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Article
Open AccessCamrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial
The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...
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Open Accessm6A regulator-mediated RNA methylation modification patterns are involved in the regulation of the immune microenvironment in ischaemic cardiomyopathy
The role of RNA N6-methyladenosine (m6A) modification in the regulation of the immune microenvironment in ischaemic cardiomyopathy (ICM) remains largely unclear. This study first identified differential m6A re...
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Open AccessTransition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer
Construction of C-N bond continues to be one part of the most significant goals in organic chemistry because of the universal applications of amines in pharmaceuticals, materials and agrochemicals. However, E2...
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Open AccessTransplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats
The endometrium plays a critical role in embryo implantation and pregnancy, and a thin uterus is recognized as a key factor in embryo implantation failure. Umbilical cord mesenchymal stem cells (UC-MSCs) have ...
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Open AccessEtiological and epidemiological features of acute respiratory infections in China
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 el...
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Open AccessEtiological, epidemiological, and clinical features of acute diarrhea in China
National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 e...
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Article
Open AccessAssociation between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients
The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled criti...
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Open AccessCorrection: Corrigendum: SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD
Scientific Reports 7: Article number: 46667; published online: 20 April 2017; updated: 22 December 2017. The original version of this Article contained errors in the numbering of affiliations where Affiliation...
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Open AccessNacre-mimic Reinforced Ag@reduced Graphene Oxide-Sodium Alginate Composite Film for Wound Healing
With the emerging of drug-resistant bacterial and fungal pathogens, there raise the interest of utilizing versatile antimicrobial biomaterials to treat the acute wound. Herein, we report the spraying mediated ...
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Open AccessSUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD
Chronic obstructive pulmonary disease(COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is ...
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Article
Open AccessNoncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle
Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective...
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Open AccessMicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection
Neuroregeneration and apoptosis are two important pathophysiologic changes after spinal cord injury (SCI), but their underlying mechanisms remain unclear. MicroRNAs (miRNAs) play a crucial role in the regulati...
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Correction: Corrigendum: Interferon regulatory factor 9 is critical for neointima formation following vascular injury
Nature Communications 5: Article number: 5160 (2014); Published: 16 October 2014; Updated: 01 April 2015 The value of the relative luciferase activity of RASMCs infected with AdshIRF9 and AdshSIRT1 in Suppleme...
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Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2–macroH2A1 (mH...
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Open AccessInterferon regulatory factor 9 is critical for neointima formation following vascular injury
Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. Here we demonstrate a critical role for IRF9 in ...
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Open AccessIRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling
Interferon regulatory factor 8 (IRF8) is known to affect the innate immune response, for example, by regulating the differentiation and function of immune cells. However, whether IRF8 can influence cardiac hyp...
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Open AccessTRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
Stroke is a leading global cause of mortality and disability. Less than 5% of patients are able to receive tissue plasminogen activator thrombolysis within the necessary timeframe. Focusing on the process of n...
