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Article
Kaempferol Attenuates Gouty Arthritis by Regulating the Balance of Th17/Treg Cells and Secretion of IL-17
Kaempferol is a common flavonoid aglycone widely found in plants. It exhibits beneficial therapeutic effects in the treatment of arthritis. However, the effects of kaempferol on gouty arthritis (GA) have not b...
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Article
Morphodynamic response of an embayed beach to different typhoon events with varying intensities
Beach erosion has occurred globally in recent decades due to frequent and severe storms. Dongsha beach, located in Zhujiajian Island, Zhejiang Province, China, is a typical embayed sandy beach. This study focu...
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Article
Extreme Cold Events in North America and Eurasia in November-December 2022: A Potential Vorticity Gradient Perspective
From 17 November to 27 December 2022, extremely cold snowstorms frequently swept across North America and Eurasia. Diagnostic analysis reveals that these extreme cold events were closely related to the establi...
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Chapter and Conference Paper
Attributed Multi-relational Graph Embedding Based on GCN
Learning low-dimensional representations of graphs is crucial for network analysis and various downstream tasks. Existing methods typically assume that only single type of relation between nodes, but, graphs o...
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Article
Quantifying the Spatial Characteristics of the Moisture Transport Affecting Precipitation Seasonality and Recycling Variability in Central Asia
Moisture contribution and transport pathways for Central Asia (CA) are quantitatively examined using the Lagrangian water cycle model based on reanalysis and observational data to explain the precipitation sea...
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Article
Open AccessRetraction Note: MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer
Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-88178-8.
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Article
CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling
Recurrent oncogenic mutations of MyD88 have been identified in a variety of lymphoid malignancies. Gain-of-function mutations of MyD88 constitutively activate downstream NF-κB signaling pathways, resulting in ...
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Article
Open AccesslncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling
MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signalin...
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Article
Open AccessA two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer
MicroRNAs (MiRNAs) have been found to be dysregulated in lung cancer tissues compared to their matched paracancerous tissues. However, the roles of miRNAs in peripheral blood as potential biomarkers for early ...
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Article
Open AccessQuantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters
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Article
Open AccessPhosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer
Both mTOR and Skp2 play critical roles in gastric cancer (GC) tumorigenesis. However, potential mechanisms for the association between these two proteins remains unidentified.
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Article
Open AccessRETRACTED ARTICLE: MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer
Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung cancer progression via Twist1-activated EMT may provide...
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Article
Skp2–MacroH2A1–CDK8 axis orchestrates G2/M transition and tumorigenesis
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2–macroH2A1 (mH...
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Article
Pollution: Clear blue skies over Bei**g
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Chapter
The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy
Lung cancer is one of the most common malignant tumors and is the leading cause of cancer mortality worldwide. However, drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue d...
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Article
MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells
MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung cancer development. However, the interact...
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Article
miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer
MicroRNAs regulate critical genes associated with lung cancer. Human mutS homolog 2 (hMSH2), one of the core mismatch repair genes, is affected in lung cancer development. The aim of this study is to investigate ...
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Article
Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells
The let-7 family of microRNAs (miRNAs) are known to act as tumor suppressors and down-regulated in lung cancer. Recently, the RNA-binding protein Lin-28 was demonstrated to inhibit biogenesis of let-7 miRNAs b...
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Article
The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells
Docosahexaenoic acid (DHA) plays an important role in suppressing the growth of cancer. In this paper, the synergetic anticancer effect of combination DHA with 5-fluorouracil (5-FU) was investigated in gastric...
