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Article
Open AccessInterstitial lung disease related to occupational hard metal exposure: two case reports
Hard metal lung disease (HMLD) is a relatively less known occupational interstitial lung disease, and instances of HMLD resulting from para-occupational exposure are rarely reported.
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Article
Lnc-IL7R alleviates PM2.5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease
Long-term exposure to PM2.5 (particulate matter with an aerodynamic diameter of ≤ 2.5 μm) is associated with pulmonary injury and emphysema in patients with chronic obstructive pulmonary disease (COPD). We invest...
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Article
3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway
Exposure to environmental and occupational contaminants leads to lung cancer. 3-Nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one, 3-NBA) is a potential carcinogen in ambient air or diesel particulate matt...
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Article
Open AccessAssociation of air pollution exposure with exercise-induced oxygen desaturation in COPD
There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O2 desaturation during exe...
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Article
Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy
Epidemiological studies identified the relationship between air pollution and pulmonary tuberculosis. Effects of lung-deposited dose of particulate matter (PM) on culture-positive pulmonary tuberculosis remain...
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Article
Recruitment maneuvers in patients undergoing thoracic surgery: a meta-analysis
Pulmonary atelectasis is a common postoperative complication that may lead to intrapulmonary shunt, refractory hypoxemia, and respiratory distress. Recruitment maneuvers may relieve pulmonary atelectasis in pa...
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Open AccessSuppressor of variegation 3–9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD
Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the T...
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Article
Open AccessBruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are current standard of care for patients with EGFR mutation and metastatic non-small-cell lung carcinoma (NSCLC), but most patients us...
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Article
Open AccessResuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses
Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients’ conditio...
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Open AccessCorrelation between early clinical exposure environment, attitudes toward basic medicine, and medical students’ basic science learning performance
Early clinical exposure (ECE) is viewed as a way to provide contexts of basic science and highlight its relevance to medical practice. However, very few studies have specifically looked into how the ECE experi...
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Open AccessCorrection: Corrigendum: SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD
Scientific Reports 7: Article number: 46667; published online: 20 April 2017; updated: 22 December 2017. The original version of this Article contained errors in the numbering of affiliations where Affiliation...
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Open AccessSUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD
Chronic obstructive pulmonary disease(COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is ...
