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Article
Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
To explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
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Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
Prediction model for develo** neuropsychiatric systemic lupus erythematosus in lupus patients
This study aimed to construct a predictive model for assessing the risk of development of neuropsychiatric systemic lupus erythematosus (NPSLE) among patients with SLE based on clinical, laboratory, and meteor...
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Article
PRDX1 Interfering Peptide Disrupts Amino Acids 70–90 of PRDX1 to Inhibit the TLR4/NF-κB Signaling Pathway and Attenuate Neuroinflammation and Ischemic Brain Injury
Ischemic stroke ranks among the leading causes of death and disability in humans and is accompanied by motor and cognitive impairment. However, the precise mechanisms underlying injury after stroke and effecti...
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Article
High dimensional proteomic map** of bone marrow immune characteristics in immune thrombocytopenia
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the sing...
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Article
Open AccessThe association of regional block with intraoperative opioid consumption in patients undergoing video-assisted thoracoscopic surgery: a single-center, retrospective study
Regional block, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), or serratus anterior plane block (SAPB) has been recommended to reduce postoperative opioid use in recent guideli...
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Article
Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN).
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Article
Translation, cultural adaptation, and validation of the Chinese standardized outcomes in nephrology–hemodialysis fatigue (C-SONG–HD fatigue) scale: a study of Chinese patients undergoing hemodialysis
This study aimed to translate and culturally adapt the standardized outcomes in nephrology–hemodialysis fatigue (SONG–HD fatigue) scale and to assess the psychometric properties of the Chinese version of the S...
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Article
Open AccessBiomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological f...
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Article
Temporal dynamics of the microbial heterogeneity–diversity relationship in microcosmic systems
Spatial heterogeneity significantly enhances biodiversity, representing one of the ecology's most enduring paradigms. However, many studies have found decreasing, humped, and neutral correlations between spati...
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Article
Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis
Systemic lupus erythematosus is a complex autoimmune disorder, and evidence supports the significance of genetic polymorphisms in SLE genetic susceptibility. The aim of this study was to assess the effects of ...
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Article
Open AccessCharacteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1
Antiretroviral therapy (ART) can reduce viral load in individuals infected with human immunodeficiency virus (HIV); however, some HIV-infected individuals still cannot achieve optimal immune recovery even afte...
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Article
Open AccessHuman urinary cells for functional wound healing with sweat gland restoration
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Article
Two annular CsI(Tl) detector arrays for the charged particle telescopes
In this study, we constructed two annular detector arrays comprising 24 wedge-shaped CsI(Tl) crystals, and tested them using an \(\alpha\) ...
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Article
Open AccessSpatio-temporal disparities of Clonorchis sinensis infection in animal hosts in China: a systematic review and meta-analysis
Clonorchis sinensis, one of the most important food-borne zoonotic trematodes, remains prevalent in China. Understanding its infection status in animals is crucial for controlling human clonorchiasis. Here we con...
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Article
Open AccessAponermin or placebo in combination with thalidomide and dexamethasone in the treatment of relapsed or refractory multiple myeloma (CPT-MM301): a randomised, double-blinded, placebo-controlled, phase 3 trial
Aponermin, a circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, is a potential death receptor 4/5-targeted antitumour candidate. Previous phase 1/2 studies have demonstrated the effic...
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Article
Microstructure and bactericidal properties of Cu-MOF, Zr-MOF and Fe-MOF
Materials derived from metal-organic frameworks (MOFs) have found extensive applications in various antimicrobial uses in recent years. Transition metals have undergone extensive research due to their exceptio...
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Article
Does the last 20 years paradigm of clinical research using volatile organic compounds to non-invasively diagnose cancer need to change? Challenges and future direction
Volatile organic compounds (VOCs) have shown great potential as novel biomarkers for cancer detection; however, comprehensive quantitative analysis is lacking. In this study, we performed a bibliometric analys...
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Article
Systemic lupus erythematosus with high disease activity identification based on machine learning
Clinical evaluation of systemic lupus erythematosus (SLE) disease activity is limited and inconsistent, and high disease activity significantly, seriously impacts on SLE patients. This study aims to generate a...
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Article
Open AccessProtocol of a multicenter, single-blind, randomized, parallel controlled trial evaluating the effect of microbiological rapid on-site evaluation (M-ROSE) guiding anti-infection treatment in patients with severe hospital-acquired pneumonia
The mortality rate of hospitalized patients with severe hospital-acquired pneumonia (SHAP) remains high. Empirical broad-spectrum antibiotic coverage and the misuse of high-grade antibiotics could lead to the ...
