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Microstructure and bactericidal properties of Cu-MOF, Zr-MOF and Fe-MOF

铜、铁和锆三种金属有机框架的微观结构与抗菌性能

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Abstract

Materials derived from metal-organic frameworks (MOFs) have found extensive applications in various antimicrobial uses in recent years. Transition metals have undergone extensive research due to their exceptional efficiency, low toxicity, and affordability. In this paper, three typical transition metal MOFs, copper (Cu-MOF), iron (Fe-MOF) and zirconium (Zr-MOF), are characterized in detail microscopically and their antimicrobial properties are systematically compared. The synthesis and microstructure of MOFs were validated using various instruments, such as SEM and PXRD. The investigation into bacterial (E. coli) test results revealed that the bactericidal effects of Cu-MOF, Fe-MOF, and Zr-MOF followed a descending order. Furthermore, the solution containing Cu-MOF displayed zero colonies in the same environment, demonstrating a 100% lethality against E. coli, a result significantly higher than the other two groups. Nevertheless, Fe-MOF and Zr-MOF exhibited an increase in antimicrobial properties of 2.47% and 73.56%, respectively, after exposure to light, both of which still demonstrated outstanding bactericidal effects.

摘要

**年来, 有机金属框架(MOFs)材料在各种抗菌领域得到广泛应用。过渡金属由于其生物相容性 **、毒性弱, 成本低而得到广泛研究。本文对三种典型的过渡金属MOFs, 铜(Cu-MOF)、铁(Fe-MOF) 和锆(Zr-MOF)的抗菌性能进行系统的比较。使用SEM和PXRD等仪器对MOFs的合成和微观结构进行 验证和表征。对细菌(大肠杆菌)的试验结果表明, Cu-MOF、Fe-MOF和Zr-MOF的杀菌效果依次减弱。 在相同的环境中, 含有Cu-MOF的溶液中菌落数为0, 表示了对大肠杆菌为100%的致死率, 这一结果 显著高于其他两组。但是暴露于光照后, Fe-MOF和Zr-MOF的抗菌性能分别提高了2.47%和73.56%, 同样表现出优异的杀菌效果。

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai, 519082, China

    Fu-yan Kang  (康福炎), Yong-** Su  (苏永进), **-zhe Huang  (黄希哲), Zi-long Zhao  (赵子龙) & Fa-qian Liu  (刘法谦)

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  1. Fu-yan Kang  (康福炎)
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Contributions

The overarching research goals were developed by ZHAO Zi-long and KANG Fu-yan. SU Yong-** and LIU Fa-qian provided the measured landslides displacement data and analyzed the measured data. HUANG **-zhe analyzed the calculated results. The initial draft of the manuscript was written by KANG Fu-yan. ZHAO Zi-long edited the draft of the manuscript. All authors replied to reviewers’ comments and revised the final version.

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Correspondence to Zi-long Zhao  (赵子龙) or Fa-qian Liu  (刘法谦).

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KANG Fu-yan, SU Yong-**, LIU Fa-qian, HUANG **-zhe and ZHAO Zi-long declare that they have no conflict of interest.

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Foundation item: Project(52073311) supported by the National Natural Science Foundation of China; Project(2021A1515012281) supported by the Guangdong Basic and Applied Basic Research Foundation, China

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Kang, Fy., Su, Yj., Huang, Xz. et al. Microstructure and bactericidal properties of Cu-MOF, Zr-MOF and Fe-MOF. J. Cent. South Univ. 30, 3237–3247 (2023). https://doi.org/10.1007/s11771-023-5471-9

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