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Article
Open AccessSingle-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a special population influenced by immunosenescence, are more sus...
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Article
Open AccessA Clinical Bacterial Dataset for Deep Learning in Microbiological Rapid On-Site Evaluation
Microbiological Rapid On-Site Evaluation (M-ROSE) is based on smear staining and microscopic observation, providing critical references for the diagnosis and treatment of pulmonary infectious disease. Automati...
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Article
Effect of Blood Circulation in Veins on Resonance Suppression of the Dragonfly Wing Constructed by Numerical Method
To reveal the resonance suppression mechanism of the blood circulation in dragonfly wings, a numerical modeling method of dragonfly wings based on Voronoi diagrams is proposed, and the changes in mass, aerodyn...
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Article
Open AccessReal-world effectiveness of nirmatrelvir-ritonavir versus azvudine in hospitalized patients with COVID-19 during the omicron wave in Bei**g: a multicenter retrospective cohort study
Two oral antivirals (Nirmatrelvir- ritonavir and Azvudine) are widely used in China practice during the Omicron wave of the pandemic. However, little evidence regarding the real-world effectiveness of these tw...
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Article
Open AccessHighly sensitive piezoresistive and thermally responsive fibrous networks from the in situ growth of PEDOT on MWCNT-decorated electrospun PU fibers for pressure and temperature sensing
Flexible electronics have demonstrated various strategies to enhance the sensory ability for tactile perception and wearable physiological monitoring. Fibrous microstructures have attracted much interest becau...
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Article
Open AccessProtocol of a multicenter, single-blind, randomized, parallel controlled trial evaluating the effect of microbiological rapid on-site evaluation (M-ROSE) guiding anti-infection treatment in patients with severe hospital-acquired pneumonia
The mortality rate of hospitalized patients with severe hospital-acquired pneumonia (SHAP) remains high. Empirical broad-spectrum antibiotic coverage and the misuse of high-grade antibiotics could lead to the ...
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Article
Nitrogen Modulates the Effects of Heat, Drought, and Combined Stresses on Photosynthesis, Antioxidant Capacity, Cell Osmoregulation, and Grain Yield in Winter Wheat
Longer and more intense heat and drought stresses will occur in terrestrial ecosystems in the future. Although the effects of individual heat or drought stress on wheat plants have been largely explored, the r...
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Article
Open AccessAuNPs and 2D functional nanomaterial-assisted SPR development for the cancer detection: a critical review
Cancer ranks as a leading cause of death and a huge obstacle to rising life expectancy. If cancers are spotted early there's a high chance of survival. The conventional methods relying on the phenotypic featur...
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Article
Open AccessProspective study of the serum Aspergillus-specific IgG, IgA and IgM assays for chronic pulmonary aspergillosis diagnosis
Chronic pulmonary aspergillosis (CPA) is an underdiagnosed and misdiagnosed disease and now increasingly recognised. However, the diagnosis of CPA remains challenging. In this study, we aimed to investigate th...
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Article
Immunodeficiency in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD), characterized by progressive airway inflammation and irreversible airflow limitation, leads to serious decline in life quality. The acute exacerbation of COPD (AEC...
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Article
SchA–p85–FAK complex dictates isoform-specific activation of Akt2 and subsequent PCBP1-mediated post-transcriptional regulation of TGFβ-mediated epithelial to mesenchymal transition in human lung cancer cell line A549
A post-transcriptional pathway by which TGF-β modulates expression of specific proteins, Disabled-2 (Dab2) and Interleukin-like EMT Inducer (ILEI), inherent to epithelial to mesenchymal transition (EMT) in mur...
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Chapter and Conference Paper
A Method of Data Flow Diagram Drawing Based on Word Segmentation Technique
The drawing of Data Flow Diagram (DFD) is the key technology in the development of system analysis and design. DFD is not only the key composing part of the logic model in new system, but also the key basis in...
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Article
Open AccessClinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China
Several reports have associated Staphylococcus lugdunensis with the incidence of severe infection in humans; however, the frequency and prevalence of this microorganism and thus the propensity of its antimicrobia...
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Chapter and Conference Paper
The Mobile Interfaces for Geo-hypermedia Databases
With the latest development of wireless networks and high performance handheld devices, web applications are no longer bounded within the desktop platforms. Many services targeting individual users are already...
