-
Article
Open AccessColorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one key driver involved in the initiation and progression of CRC. However, mutations of APC gene in CRC patients retain c...
-
Article
Open AccessIncorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases
mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases. Improvements of mRNA vaccines have been underway, a...
-
Article
Open AccessSCGN deficiency is a risk factor for autism spectrum disorder
Autism spectrum disorder (ASD) affects 1–2% of all children and poses a great social and economic challenge for the globe. As a highly heterogeneous neurodevelopmental disorder, the development of its treatmen...
-
Article
Open AccessAn integrated map of fibroblastic populations in human colon mucosa and cancer tissues
Fibroblasts and myofibroblasts are major mesenchymal cells in the lamina propria of colon mucosa and in colon cancer tissues. Detailed insight into the highly specific populations of fibroblasts and myofibrobl...
-
Article
Open AccessPrognostic value and biological function of LRRN4 in colorectal cancer
Several nervous and nerve-related biomarkers have been detected in colorectal cancer (CRC) and can contribute to the progression of CRC. However, the role of leucine-rich repeat neuronal 4 (LRRN4), a recently ...
-
Article
Open AccessGMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB
The congenital disorders of glycosylation (CDG) are a family of metabolic diseases in which glycosylation of proteins or lipids is deficient. GDP-mannose pyrophosphorylase B (GMPPB) mutations lead to CDG, char...
-
Article
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis
GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis, and aberrant cellular GDP-Man levels have been associated with multiple human disea...
-
Article
Open AccessComputational flow cytometric analysis to detect epidermal subpopulations in human skin
The detection and dissection of epidermal subgroups could lead to an improved understanding of skin homeostasis and wound healing. Flow cytometric analysis provides an effective method to detect the surface ma...
-
Article
Open AccessIntraperitoneal extraosseous osteosarcoma: a case report and literatures review
To investigate the clinical imaging manifestations, diagnosis and treatment of intraperitoneal extraosseous osteosarcoma.
-
Article
Open AccessBilateral synovial chondromatosis of the elbow in an adolescent: a case report and literature review
Primary synovial chondromatosis is a rare benign disease that occurs in the joint mucosa.
-
Article
Human circulating and tissue gastric cancer stem cells display distinct epithelial–mesenchymal features and behaviors
Metastasis is a leading cause of cancer-related-deaths worldwide. Recently, cancer stem cells (CSCs) have been believed to be responsible for tumor initiation and metastasis, but till now, difference of cellul...
-
Article
Open AccessNeurons generated from carcinoma stem cells support cancer progression
Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The st...
-
Article
Open AccessSyndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis
Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan (HSPG), plays significant role in the formation of focal adhesions and interacts with many growth factors to regulate cell migration...
-
Article
Open AccessHyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer
Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance in non-small cell lung cancer (NSCLC) is poo...
-
Article
Isolation and characterization of circulating tumor cells from human gastric cancer patients
Circulating tumor cells (CTCs) have been proved to be responsible for tumor metastasis and resistant to anticancer therapies. This study aims to isolate and characterize circulating tumor cells from human gas...
-
Article
Open AccessTLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis
Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny that undergo terminal differentiation. However, the fine m...
-
Article
Open AccessSnail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos
The Snail family member snail encodes a zinc finger-containing transcriptional factor that is involved in heart formation. Yet, little is known about how Snail regulates heart development. Here, we identified tha...
-
Article
Single primary fetal lung cells generate alveolar structures in vitro
Organ morphogenesis, including lung morphogenesis, involves a series of cellular behaviors that are difficult to observe and document in vivo due to current limitations in imaging techniques. Therefore, in vit...
-
Article
Open AccessBAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer
The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of ...
-
Article
A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy
Hypoxia has been found to play an important role in regulating the biological characteristics of cancer stem cells (cCSCs). In this study, we tested whether a tumor hypoxic niche serves to the chemotherapeutic...
