25 Result(s)

Article

Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia

**ang-shan Yuan, Zhe **ang, Jian-bo Jiang, Fang Yuan, Mu-tian Zhang… in Cell Discovery (2024)

Article

Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9

CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...

Qi-Yue Chen, Kai-**ang Xu, **ao-Bo Huang, Deng-Hui Fan… in Communications Biology (2024)

Article

IP3R2-mediated Ca²⁺ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca²⁺) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

Article

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics. This calls for the variant-proof ...

Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan, Qian Wang… in Cell Research (2022)

Article

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...

Min Huang, Fang He, Dan Li, Ya-Jia **e, Ze-Bo Jiang, Ju-Min Huang… in Cell Death & Disease (2022)

Article

Chromosome-level genome assembly and population genomic analyses provide insights into adaptive evolution of the red turpentine beetle, Dendroctonus valens

Biological invasions are responsible for substantial environmental and economic losses. The red turpentine beetle (RTB), Dendroctonus valens LeConte, is an important invasive bark beetle from North America that h...

Zhudong Liu, Longsheng **ng, Wanlong Huang, Bo Liu, Fanghao Wan… in BMC Biology (2022)

Article

Function of PHEX mutations p.Glu145* and p.Trp749Arg in families with X-linked hypophosphatemic rickets by the negative regulation mechanism on FGF23 promoter transcription

X-linked hypophosphatemic rickets (XLH) is characterized by increased circulating fibroblast growth factor 23 (FGF23) concentration caused by PHEX (NM_000444.5) mutations. Renal tubular resorption of phosphate is...

Yu-mian Gan, Yan-** Zhang, Dan-dan Ruan, Jian-bin Huang… in Cell Death & Disease (2022)

Article

Targeting NAD+: is it a common strategy to delay heart aging?

Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numero...

Yang Yuan, Bing Liang, **n-Lin Liu, Wen-**g Liu, Bing-Huan Huang… in Cell Death Discovery (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Discovery of new genetic loci for male sexual orientation in Han population

Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Genome-wide investigation and expression profiling of polyphenol oxidase (PPO) family genes uncover likely functions in organ development and stress responses in Populus trichocarpa

Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to ab...

Fang He, Yu-Jie Shi, Qian Zhao, Kuang-Ji Zhao, **ng-Lei Cui, Liang-Hua Chen… in BMC Genomics (2021)

Article

A cohort autopsy study defines COVID-19 systemic pathogenesis

Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic d...

**ao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang… in Cell Research (2021)

Article

Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeost...

Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, **gang Zheng, Chenfeng Mao… in Cell Research (2021)

Article

Horizontally acquired antibacterial genes associated with adaptive radiation of ladybird beetles

Horizontal gene transfer (HGT) has been documented in many herbivorous insects, conferring the ability to digest plant material and promoting their remarkable ecological diversification. Previous reports sugge...

Hao-Sen Li, Xue-Fei Tang, Yu-Hao Huang, Ze-Yu Xu, Mei-Lan Chen, Xue-Yong Du… in BMC Biology (2021)

Article

Cytosine methylations in the promoter regions of genes involved in the cellular oxidation equilibrium pathways affect rice heat tolerance

High temperatures, particularly at night, decrease rice yield and quality. As high nighttime temperatures (HNTs) become increasingly frequent due to climate change, it is imperative to develop rice crops that ...

Chao He, Hong-Yu Zhang, Yong-**n Zhang, Pei Fu, Li-Li You, Wen-Bo **ao… in BMC Genomics (2020)

Article

The microbiota structure in the cecum of laying hens contributes to dissimilar H₂S production

Host genotype plays a crucial role in microbial composition of laying hens, which may lead to dissimilar odor gas production. The objective of this study was to investigate the relationship among layer breed, ...

Chun-Bo Huang, Lei **ao, Si-Cheng **ng, **g-Yuan Chen, Yi-Wen Yang… in BMC Genomics (2019)

Article

Inhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development

Skeletal muscle differentiation is controlled by multiple cell signaling pathways, however, the JNK/MAPK signaling pathway dominating this process has not been fully elucidated. Here, we report that the JNK/MA...

Shu-Juan **e, Jun-Hao Li, Hua-Feng Chen, Ye-Ya Tan… in Cell Death & Differentiation (2018)

Article

Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

Elucidating the origin of microglia is crucial for understanding their functions and homeostasis. Previous study has indicated that Nestin-positive progenitor cells differentiate into microglia and replenish t...

Yubin Huang, Zhen Xu, Shanshan **ong, Guangrong Qin, Fangfang Sun… in Cell Discovery (2018)

Article

Intravenous injections of the oncolytic virus M1 as a novel therapy for muscle-invasive bladder cancer

Muscle-invasive bladder cancer (MIBC) is associated with low survival and high recurrence rates even in cases in which patients receive systemic treatments, such as surgery and chemotherapy. Here, we found tha...

Cheng Hu, Ying Liu, Yuan Lin, Jian-Kai Liang, Wen-Wen Zhong, Ke Li… in Cell Death & Disease (2018)

Article

A genome for gnetophytes and early evolution of seed plants

Gnetophytes are an enigmatic gymnosperm lineage comprising three genera, Gnetum, Welwitschia and Ephedra, which are morphologically distinct from all other seed plants. Their distinctiveness has triggered much de...

Tao Wan, Zhi-Ming Liu, Ling-Fei Li, Andrew R. Leitch, Ilia J. Leitch… in Nature Plants (2018)