57 Result(s)

Article

Leptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia

**ang-shan Yuan, Zhe **ang, Jian-bo Jiang, Fang Yuan, Mu-tian Zhang… in Cell Discovery (2024)

Article

Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9

CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...

Qi-Yue Chen, Kai-**ang Xu, **ao-Bo Huang, Deng-Hui Fan… in Communications Biology (2024)

Article

IP3R2-mediated Ca²⁺ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway

Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca²⁺) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...

Qing-Rui Wu, Hui Yang, Hui-Dan Zhang, Yong-Jiang Cai… in Cell Death Discovery (2024)

Article

Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis

Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described; however, recent studies have shown that some non-bone-derived exoso...

** Wang, Wenkai Shao, Zilin Li, Bo Wang, **ao Lv… in Cell Communication and Signaling (2024)

Article

Biogeographic patterns of meio- and micro-eukaryotic communities in dam-induced river-reservoir systems

Although the Three Gorges Dam (TGD) is the world’s largest hydroelectric dam, little is known about the spatial–temporal patterns and community assembly mechanisms of meio- and micro-eukaryotes and its two sub...

Huan Hu, **ng-Yi Wei, Li Liu, Yuan-Bo Wang… in Applied Microbiology and Biotechnology (2024)

Article

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics. This calls for the variant-proof ...

Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan, Qian Wang… in Cell Research (2022)

Article

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...

Min Huang, Fang He, Dan Li, Ya-Jia **e, Ze-Bo Jiang, Ju-Min Huang… in Cell Death & Disease (2022)

Article

Chromosome-level genome assembly and population genomic analyses provide insights into adaptive evolution of the red turpentine beetle, Dendroctonus valens

Biological invasions are responsible for substantial environmental and economic losses. The red turpentine beetle (RTB), Dendroctonus valens LeConte, is an important invasive bark beetle from North America that h...

Zhudong Liu, Longsheng **ng, Wanlong Huang, Bo Liu, Fanghao Wan… in BMC Biology (2022)

Article

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the ...

Zhen Sun, Hua Yu, **g Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu… in Protein & Cell (2022)

Article

Function of PHEX mutations p.Glu145* and p.Trp749Arg in families with X-linked hypophosphatemic rickets by the negative regulation mechanism on FGF23 promoter transcription

X-linked hypophosphatemic rickets (XLH) is characterized by increased circulating fibroblast growth factor 23 (FGF23) concentration caused by PHEX (NM_000444.5) mutations. Renal tubular resorption of phosphate is...

Yu-mian Gan, Yan-** Zhang, Dan-dan Ruan, Jian-bin Huang… in Cell Death & Disease (2022)

Article

Targeting NAD+: is it a common strategy to delay heart aging?

Heart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numero...

Yang Yuan, Bing Liang, **n-Lin Liu, Wen-**g Liu, Bing-Huan Huang… in Cell Death Discovery (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Discovery of new genetic loci for male sexual orientation in Han population

Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Genome-wide investigation and expression profiling of polyphenol oxidase (PPO) family genes uncover likely functions in organ development and stress responses in Populus trichocarpa

Trees such as Populus are planted extensively for reforestation and afforestation. However, their successful establishment greatly depends upon ambient environmental conditions and their relative resistance to ab...

Fang He, Yu-Jie Shi, Qian Zhao, Kuang-Ji Zhao, **ng-Lei Cui, Liang-Hua Chen… in BMC Genomics (2021)

Article

A cohort autopsy study defines COVID-19 systemic pathogenesis

Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic d...

**ao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang… in Cell Research (2021)

Article

Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeost...

Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, **gang Zheng, Chenfeng Mao… in Cell Research (2021)