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Publisher Correction: Cyclolignan synthesis streamlined by enantioselective hydrogenation of tetrasubstituted olefins
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Open AccessIGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma
Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in embryonic develo...
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Article
Open AccessA large deletion conferring pale green leaves of maize
The structural basis of chloroplast and the regulation of chloroplast biogenesis remain largely unknown in maize. Gene mutations in these pathways have been linked to the abnormal leaf color phenotype observed...
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Open AccessMap** the spatial distribution of fossil geothermal manifestations and assessment of geothermal potential of the Tangyin rift, Southeast of Taihang Mountain in China
The spatial prediction of geothermal sites along the southeast side of Taihang Mountain in the Tangyin rift is a critical goal in the development of renewable energy resources in cities such as Hebi in Henan p...
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Open AccessOrgan-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice
Organ-specific metastatic context has not been incorporated into the clinical practice of guiding programmed death-(ligand) 1 [PD-(L)1] blockade, due to a lack of understanding of its predictive versus prognos...
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Open AccessClinical translation of patient-derived tumour organoids- bottlenecks and strategies
Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and precision medicine. The intrinsic ab...
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Article
Open AccessUsefulness of estimated pulse wave velocity for identifying prevalent coronary heart disease: findings from a general Chinese population
Aortic stiffness and coronary heart disease (CHD) share a similar spectrum of risk factors; previous studies have identified the association between aortic stiffness and CHD. Recent studies have demonstrated e...
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Open AccessGlobal, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...
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Open AccessRegio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
The enantioselective construction of C–CF2R (R: alkyl or fluoroalkyl) bonds has attracted the attention of synthetic chemists because of the importance of chiral fluorinated compounds in life and materials scienc...
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Open AccessPilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
The virulence of the plant pathogen Xanthomonas campestris pv. campestris (Xcc) involves the coordinate expression of many virulence factors, including surface appendages flagellum and type IV pili, which are req...
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Open AccessRisk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women
To explore the risk factors for the recurrence of endometrioma and the risk factors for the recurrence of endometriosis-related pain after long-term follow-up.
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Open AccessSafety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours
Because of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to esta...
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Open AccessTuneable near white-emissive two-dimensional covalent organic frameworks
Most two-dimensional (2D) covalent organic frameworks (COFs) are non-fluorescent in the solid state even when they are constructed from emissive building blocks. The fluorescence quenching is usually attribute...
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Open AccessRisk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary
Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women ...
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Article
Open AccessControllable deuteration of halogenated compounds by photocatalytic D2O splitting
Deuterium labeling is of great value in organic synthesis and the pharmaceutical industry. However, the state-of-the-art C–H/C–D exchange using noble metal catalysts or strong bases/acids suffers from poor fun...
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Open AccessPredictive factors of ovarian carcinoma for women with ovarian endometrioma aged 45 years and older in China
To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis (OEM) aged 45 years and above in China.
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Article
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition
TGR5 agonists stimulate intestinal glucagon-like peptide-1 (GLP-1) release, but systemic exposure causes unwanted side effects, such as gallbladder filling. In the present study, linagliptin, a DPP-4 inhibitor...
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Open AccessCyclooxygenase-2 induced β1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway
Cyclooxygenase-2 (COX-2) has been implicated in cell invasion in non-small-cell lung cancer (NSCLC). However, the mechanism is unclear. The present study investigated the effect of COX-2 on β1-integrin express...
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Open AccessFactors and Regional Differences Associated with Endometriosis: A Multi-Country, Case–Control Study
The present study aimed to investigate clinical, lifestyle, and environmental factors associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) as determined by case–control comparison [w...
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Open AccessIntestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect
TGR5 activation of enteroendocrine cells increases glucagon-like peptide 1 (GLP-1) release, which maintains glycemic homeostasis. However, TGR5 activation in the gallbladder and heart is associated with severe...
