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Chapter and Conference Paper
Immovable Pipeline Decompression and Augmented Injection Integrated Technology Apply to Low Permeability Reservoir
The low permeability sandstone reservoir of Huabei oilfield has high clay mineral content, strong sensitivity and poor reservoir physical property. It can lead to low formation energy and low well production [1]....
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Chapter and Conference Paper
Research and Field Application of New Composite Acid System for Low Permeability Sandstone Reservoir
Sandstone reservoirs in Huabei Oilfield are characterized by low porosity, low permeability, high clay content, strong heterogeneity and high reservoir temperature. In order to solve the problems of the rapid ...
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Article
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
Dipeptidyl peptidase 4 (DPP4), a ubiquitously expressed protease that cleaves off the N-terminal dipeptide from proline and alanine on the penultimate position, has important roles in many physiological proces...
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Article
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition
TGR5 agonists stimulate intestinal glucagon-like peptide-1 (GLP-1) release, but systemic exposure causes unwanted side effects, such as gallbladder filling. In the present study, linagliptin, a DPP-4 inhibitor...
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Article
Open AccessIntestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect
TGR5 activation of enteroendocrine cells increases glucagon-like peptide 1 (GLP-1) release, which maintains glycemic homeostasis. However, TGR5 activation in the gallbladder and heart is associated with severe...
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Article
Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with the ability to ameliorate metabolic disorders in diet-induced obes...
