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Article
Open AccessSource apportionment of PM2.5 using DN-PMF in three megacities in South Korea
PM2.5 pollution is problematic in megacities on the western coast in South Korea (Seoul, Incheon, and Gwangju). As these megacities are located downwind of China, their air quality is easily affected by local and...
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Article
Open AccessDistinctive CD56dim NK subset profiles and increased NKG2D expression in blood NK cells of Parkinson’s disease patients
Mounting data suggest an important role for the immune system in Parkinson’s disease (PD). Previous evidence of increased natural killer (NK) cell populations in PD suggests a potential role of NK cells in the...
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Article
Open Accessc-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
Endocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge that poses several unmet needs in the management of the disease. This ...
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Open AccessUltra-stable and tough bioinspired crack-based tactile sensor for small legged robots
For legged robots, collecting tactile information is essential for stable posture and efficient gait. However, mounting sensors on small robots weighing less than 1 kg remain challenges in terms of the sensor’...
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Open AccessSpider-inspired tunable mechanosensor for biomedical applications
The recent advances of wearable sensors are remarkable but there are still limitations that they need to be refabricated to tune the sensor for target signal. However, biological sensory systems have the inher...
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Article
Multivariable Technique for the Evaluation of the Trans-stenotic Pressure Gradient
This study establishes a reliable image-based multivariable technique for measuring the trans-stenotic pressure gradient.
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Article
Open AccessImplication of high variance in germplasm characteristics
The beauty of conserving germplasm is the securement of genetic resources with numerous important traits, which could be utilized whenever they need to be incorporated into current cultivars. However, it would...
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Open AccessAuthor Correction: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the develo** mouse brain and human neurons
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Health effects of PM2.5 constituents and source contributions in major metropolitan cities, South Korea
Ambient PM2.5 is one of the major risk factors for human health, and is not fully explained solely by mass concentration. We examined the short-term associations of cause-specific mortality (i.e., all-cause, card...
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Article
Hemodynamics in a three-dimensional printed aortic model: a comparison of four-dimensional phase-contrast magnetic resonance and image-based computational fluid dynamics
This study aims to compare an electrocardiogram (ECG)-gated four-dimensional (4D) phase-contrast (PC) magnetic resonance imaging (MRI) technique and computational fluid dynamics (CFD) using variables controlle...
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Open AccessUsefulness of estimated pulse wave velocity for identifying prevalent coronary heart disease: findings from a general Chinese population
Aortic stiffness and coronary heart disease (CHD) share a similar spectrum of risk factors; previous studies have identified the association between aortic stiffness and CHD. Recent studies have demonstrated e...
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Article
Case study: cost-effective image analysis method to study drought stress of soybean in early vegetative stage
There are many applications of image-based analysis for phenoty** agronomic traits. However, they are inappropriate or difficult to operate due to lack of time, equipment, and financial limits. In this repor...
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Open AccessThe impact of organic extracts of seasonal PM2.5 on primary human lung epithelial cells and their chemical characterization
Lung epithelial cells serve as the first line of defense against various inhaled pollutant particles. To investigate the adverse health effects of organic components of fine particulate matter (PM2.5) collected i...
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Article
Open AccessTanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the develo** mouse brain and human neurons
mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. However, we do not fully understand all of the upstream signaling co...
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Article
Open AccessRisk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia
Carbapenem is frequently used when gram negative bacilli (GNB) bacteremia is detected especially in neutropenic patients. Consequently, appropriate treatment could be delayed in GNB bacteremia cases involving ...
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Article
Open AccessATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
Maintaining stability of replication forks is important for genomic integrity. However, it is not clear how replisome proteins contribute to fork stability under replication stress. Here, we report that ATAD5,...
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Article
Stand der interkulturellen Öffnung der Einrichtungen im Pflegebereich in Berlin
In Zeiten des demografischen Wandels in Deutschland kann die Prognose gestellt werden, dass immer mehr ältere Migrant*innen ins System der Altenhilfe und Altenpflege rücken werden. Es ist aber festzustellen, d...
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Open AccessRegulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). It remains controversial how RFC and RLCs cooperate to regulate PCNA load...
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Article
Open AccessA Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer
The epidermal growth factor receptor (EGFR) inhibitors such as erlotinib and gefitinib are widely used for treatment of non-small cell lung cancer (NSCLC), but they have shown limited efficacy in an unselected...
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Open AccessA small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab
Drugs targeting the epidermal growth factor receptor (EGFR), such as cetuximab and panitumumab, have been prescribed for metastatic colorectal cancer (CRC), but patients harboring KRAS mutations are insensitive t...
