![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
-
Article
Erratum: The sequence and de novo assembly of the giant panda genome
Nature 463, 311–317 (2010) In this Article, the Latin species name of the giant panda was written incorrectly as Ailuropoda melanoleura. The correct name is Ailuropoda melanoleuca.
-
Article
Ordered bilayer ruthenium–platinum core-shell nanoparticles as carbon monoxide-tolerant fuel cell catalysts
Fabricating subnanometre-thick core-shell nanocatalysts is effective for obtaining high surface area of an active metal with tunable properties. The key to fully realize the potential of this approach is a rel...
-
Article
Open AccessDraft genome sequence of the mulberry tree Morus notabilis
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through the Silk Road. Complementing the silkworm genome sequence, here we describe ...
-
Article
Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer
Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, there...
-
Article
Benzene construction via organocatalytic formal [3+3] cycloaddition reaction
The benzene unit, in its substituted forms, is a most common scaffold in natural products, bioactive molecules and polymer materials. Nearly 80% of the 200 best selling small molecule drugs contain at least on...
-
Article
Open AccessThe draft genome of the large yellow croaker reveals well-developed innate immunity
The large yellow croaker, Larimichthys crocea, is one of the most economically important marine fish species endemic to China. Its wild stocks have severely suffered from overfishing, and the aquacultured species...
-
Article
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) acros...
-
Article
Open AccessPredicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial
Tripterygium wilfordii Hook F. (TwHF) based therapy has been proved as effective in treating rheumatoid arthritis (RA), yet the predictors to its response remains unclear. A two-stage trial was designed to identi...
-
Article
Open AccessAn integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids
Traditional herbal medicines adulterated and contaminated with plant materials from the Aristolochiaceae family, which contain aristolochic acids (AAs), cause aristolochic acid nephropathy. Approximately 256 t...
-
Article
Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1
Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 ...
-
Article
Open AccessBlood lead level and its association with body mass index and obesity in China - Results from SPECT-China study
We aimed to report environmental and blood lead level (BLL) in China and investigate the relationship of BLL with body mass index (BMI) and obesity. 5558 subjects were enrolled from 16 sites in China. BLL was ...
-
Article
Open AccessDihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts
Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients’ quality of life. It is believed that the crosstalk between metastatic b...
-
Article
Y-chromosomes from skeletal remains of Chinese Expeditionary Force offer a clue to their paternal relatives
-
Article
Open AccessIdentification of Liver Epithelial Cell-derived Ig Expression in μ chain-deficient mice
Growing evidence indicates that B cells are not the only source of immunoglobulin (Ig). To investigate this discovery further, we used μMT mice, which have a disruption of the first transmembrane exon of the μ...
-
Article
Open AccessMetabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processing
Pinelliae Rhizoma (PR) is a commonly used Chinese medicinal herb, but it has been frequently reported about its toxicity. According to the traditional Chinese medicine theory, processing can reduce the toxicit...
-
Article
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
YAP and TAZ, effectors of the Hippo pathway, sense mechanical forces generated by blood flow and play a role in atherosclerosis pathogenesis.
-
Article
Open AccessA Mott insulator continuously connected to iron pnictide superconductors
Iron-based superconductivity develops near an antiferromagnetic order and out of a bad-metal normal state, which has been interpreted as originating from a proximate Mott transition. Whether an actual Mott ins...
-
Article
Open AccessOvercoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors
Sorafenib is a RAF inhibitor approved for several cancers, including hepatocellular carcinoma (HCC). Inhibition of RAF kinases can induce a dose-dependent “paradoxical” upregulation of the downstream mitogen-a...
-
Article
Open AccessCadmium exposure and its association with serum uric acid and hyperuricemia
Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared ...