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Article
Green synthesis of luminescent La-MOF nanoparticle from waste poly(ethylene terephthalate) for high-performance in Fe(III) detection
Develo** luminescent metal–organic frameworks (MOFs) capable of high-efficiency Fe3+ sensing has aroused great attraction in the fields of biology, chemistry, etc. However, previous solvothermal methods are lim...
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Article
A widely used nonionic surfactant with desired functional groups as aqueous electrolyte additives for stabilizing Zn anode
Aqueous Zn-ion batteries (AZIBs) have emerged as potential candidates for Li-ion batteries due to their intrinsic safety and high capacity. However, metallic Zn anodes encounter dendrite growth and water-induc...
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Article
Energy band modulation of N-doped rutile/anatase TiO2 photoanode promoting charge separation toward prominent photoelectrochemical performance
To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO2-based materials, a simple N-doped anatase/rutile TiO2 heterophase nanorod film was design...
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Article
Finite-temperature ductility-brittleness and electronic structures of AlnSc (n = 1, 2 and 3)
Finite-temperature ductility-brittleness and electronic structures of Al3Sc, Al2Sc and AlSc are studied comparatively by first-principles calculations and ab initio molecular dynamics. Results show that Al3Sc and...
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Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Article
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...
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Article
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Article
N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is one of its common symptoms which lacks effective treatment. N...
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Article
Antibody–drug conjugates in gastric cancer: from molecular landscape to clinical strategies
Antibody–drug conjugates (ADCs) represent a crucial component of targeted therapies in gastric cancer, potentially altering traditional treatment paradigms. Many ADCs have entered rigorous clinical trials base...
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Article
Copper-catalyzed enantioselective desymmetrizing C(sp2)–H functionalization of azide-ynamides via α-imino copper carbenes
α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on
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Article
Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
To investigate the potential role of Tongxinluo (TXL) in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury (MIRI) in mice.
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Article
H-Louvain: Hierarchical Louvain-based community detection in social media data streams
The rise of online social networks has fundamentally transformed the traditional way of social interaction and information dissemination, leading to a growing interest in precise community detection and in-dep...
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Article
DIEET: Knowledge–Infused Event Tracking in Social Media based on Deep Learning
The rapid expansion of the mobile Internet has led to online social networks becoming an increasingly integral part of our daily lives, this offers a new perspective in the study of human behavior. Existing me...
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Article
Theoretical Exploration of Alloying Effects on Stabilities and Mechanical Properties of γʹ Phase in Novel Co–Al–Nb-Base Superalloys
The new developed γ/γʹ Co–Al–Nb-base alloys show great potentials as high-temperature materials. However, finding appropriate compositions to improve performance of alloys still poses a great challenge to the dev...
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Open AccessHyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy
Bacteria-mediated cancer therapeutic strategies have attracted increasing interest due to their intrinsic tumor tropism. However, bacteria-based drugs face several challenges including the large size of bacter...
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Article
Preparation of UiO-66-NH2@cellulose nanofiber composite film and its adsorption performance study towards Cd(II)
A novel heavy metal ion adsorbent, UiO-66-NH2@cellulose nanofiber membrane, was successfully synthesized using cellulose and polyvinyl alcohol as substrates and UiO-66-NH2 as the loading material. The adsorption ...
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Article
Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
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Article
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment both as a monotherapy or in combin...
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Article
Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury
Inflammatory macrophage infiltration plays a critical role in acute kidney disease induced by ischemia-reperfusion (IRI-AKI). Calycosin is a natural flavone with multiple bioactivities. This study aimed to inv...
