392 Result(s)

Article

IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages

In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...

Jiayu Zhang, Yu Dong, Shan Yu, Keshu Hu, Lingyun Zhang, Min **ong… in Cell Death & Disease (2024)

Article

PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3

The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...

Jia-Teng Sun, Zi-Mu Wang, Liu-Hua Zhou, Tong-Tong Yang, Di Zhao… in Communications Biology (2024)

Article

Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice

Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main cause of childhood blindness. Nowadays anti-VEGF and retinal photocoagu...

Yatu Guo, Jiahui Qin, Ruiqiang Sun, Peng Hao, Zhixin Jiang… in Biological Research (2024)

Article

A multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome

The human vagina harbours diverse microorganisms—bacteria, viruses and fungi—with profound implications for women’s health. Genome-level analysis of the vaginal microbiome across multiple kingdoms remains limi...

Liansha Huang, Ruochun Guo, Shenghui Li, **aoling Wu, Yue Zhang… in Nature Microbiology (2024)

Article

A comprehensive analysis of the WRKY family in soybean and functional analysis of GmWRKY164-GmGSL7c in resistance to soybean mosaic virus

Soybean mosaic disease caused by soybean mosaic virus (SMV) is one of the most devastating and widespread diseases in soybean producing areas worldwide. The WRKY transcription factors (TFs) are widely involved in...

Zhihua Zhao, Rongna Wang, Weihua Su, Tianjie Sun, Mengnan Qi, Xueyan Zhang… in BMC Genomics (2024)

Article

Comparative profiling of serum, urine, and feces bile acids in humans, rats, and mice

Bile acids (BAs) play important pathophysiological roles in both humans and mammalian animals. Laboratory rats and mice are widely used animal models for assessing pharmacological effects and their underlying ...

Dan Zheng, Kun Ge, Chun Qu, Tao Sun, Jieyi Wang, Wei Jia… in Communications Biology (2024)

Article

Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction

Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye diseases. Here, we reported that the kri1l gene was responsible for ...

Rong Zhang, Jiajun Sun, Yabin **e, Wei Zhu, Meitong Tao, Yu Chen… in Cell Death Discovery (2024)

Article

IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway

Studies have shown that hepatic stellate cells (HSCs) and interleukin-17a (IL-17a) play important roles in liver tumorigenesis. In addition, fibroblast activation protein-α (FAP) has been shown to be a key reg...

Dapeng Sun, Wen Li, Dongyang Ding, Kunjiang Tan, Wenbin Ding… in Cell Death Discovery (2024)

Article

FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development

Ovarian cancer (OV) poses a significant challenge in clinical settings due to its difficulty in early diagnosis and treatment resistance. FOXP4, belonging to the FOXP subfamily, plays a pivotal role in various...

**g Ji, Qilan Qian, Wenhao Cheng, **aoqing Ye, Aixin **g… in Cell Death & Disease (2024)

Article

CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity

The incidence of autoimmune diseases has significantly increased over the past 20 years. Excessive host immunoreactions and disordered immunoregulation are at the core of the pathogenesis of autoimmune disease...

Hantian Liang, **nzou Fan, Hao Cheng, **ao Ma, Yutong Sun, Fang Nan… in Cell Death Discovery (2024)

Article

Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells

Irradiation (IR) induces immunogenic cell death (ICD) in tumors, but it rarely leads to the abscopal effect (AE); even combining IR with immune checkpoint inhibitors has shown only anecdotal success in inducin...

Wei Guo, Lin Jia, Ling **e, Juliann G. Kiang, Yangyang Wang… in Cell Death & Disease (2024)

Article

MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway

Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated...

Lei Yan, Ruhao Zhou, Yi Feng, Ruoqi Li, Long Zhang, Yongchun Pan… in Cell Death Discovery (2024)

Article

Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression

Isochlorate dehydrogenase 1 (IDH1) is an important metabolic enzyme for the production of α-ketoglutarate (α-KG), which has antitumor effects and is considered to have potential antitumor effects. The activati...

Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao… in Cell Death & Disease (2024)

Article

Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically char...

Meng Wu, Weicheng Tang, Ying Chen, Liru Xue, Jun Dai, Yan Li, **aoran Zhu… in Nature Aging (2024)

Article

Phylogenomics resolves the higher-level phylogeny of herbivorous eriophyoid mites (Acariformes: Eriophyoidea)

Eriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The higher-level phylogeny of eriophyoid mites, however, remains unresolved due to the limited n...

Qi Zhang, Yi-Wen Lu, **n-Yu Liu, Ye Li, Wei-Nan Gao, **g-Tao Sun… in BMC Biology (2024)

Article

Characterization of sucrose nonfermenting-1-related protein kinase 2 (SnRK2) gene family in Haynaldia villosa demonstrated SnRK2.9-V enhances drought and salt stress tolerance of common wheat

The sucrose nonfermenting-1-related protein kinase 2 (SnRK2) plays a crucial role in responses to diverse biotic/abiotic stresses. Currently, there are reports on these genes in Haynaldia villosa, a diploid wild ...

Jia Liu, Luyang Wei, Yirong Wu, Zongkuan Wang, Haiyan Wang, ** **ao… in BMC Genomics (2024)

Article

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to ...

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, **aohua Chen, Boyi Yu… in Cell Death & Disease (2024)

Article

Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

Adenine base editors (ABEs) and cytosine base editors (CBEs) enable the single nucleotide editing of targeted DNA sites avoiding generation of double strand breaks, however, the genomic features that influence...

Tanglong Yuan, Leilei Wu, Shiyan Li, Jitan Zheng, Nana Li, **ao **ao… in Cell Discovery (2024)

Article

Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing

CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur...

Juan-Juan Zhao, **n-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin… in BMC Genomics (2024)

Article

Retraction Note: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway

**-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen… in Cell Death & Disease (2024)