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Article
Open AccessMolecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main cause of childhood blindness. Nowadays anti-VEGF and retinal photocoagu...
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Article
Quantitative assessment of hyperperfusion using arterial spin labeling to predict hemorrhagic transformation in acute ischemic stroke patients with mechanical endovascular therapy
This study was aimed to quantitatively assess hyperperfusion using arterial spin labeling (ASL) to predict hemorrhagic transformation (HT) in acute ischemic stroke (AIS) patients.
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Article
Method for Predicting Service Life of Cage Throttle Valves
The throttle valve is vital in the oil and gas production stage, designed to decrease natural gas pressure at the wellhead to match transportation pipeline standards. During this process, its flow rate sharply...
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Article
Conformation of an Amphiphilic Comb-like Copolymer in a Selective Solvent
We study the conformation of an amphiphilic comb-like copolymer in a selective solvent by using Brownian dynamics simulations. Our results demonstrate that, there is an optimal total degree of polymerization t...
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Article
Neuronal differentiation and functional maturation of neurons from neural stem cells induced by bFGF-chitosan controlled release system
Available methods for differentiating stem cells into neurons require a large number of cytokines and neurotrophic factors, with complex steps and slow processes, and are inefficient to produce functional neur...
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Article
Open AccessMicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
Inflammation is a key factor in the pathogenesis of dry eye disease (DED). We aimed to investigate the role of microRNA-146a (miR-146a) in regulating corneal inflammation in a mouse model of benzalkonium chlor...
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Article
Open AccessCharacterization of 17β-estradiol-degrading enzyme from Microbacterium sp. MZT7 and its function on E2 biodegradation in wastewater
17β-estradiol (E2) residues exhibit harmful effects both for human and animals and have got global attention of the scientific community. Microbial enzymes are considered as one of the effective strategies hav...
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Article
ERRα contributes to HDAC6-induced chemoresistance of osteosarcoma cells
Chemotherapy resistance is an important problem for clinical therapy of osteosarcoma (OS). The potential effects of histone deacetylases (HDACs) on OS chemoresistance are studied. The expression of HDACs in OS...
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Article
Quantities vs. prices: monopoly regulation without transfer under asymmetric demand information
This paper examines the optimal monopoly regulation without transfer based on Basso, Figueroa and Vásquez (Rand J Econ 48(3):557–578, 2017), which compare the quantity-based and price-based instruments to regu...
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Article
Multigrid reduced-order topology optimization scheme for structures subjected to stationary random excitations
Topology optimization methods for structures subjected to random excitations are difficult to widely apply in aeronautic and aerospace engineering, primarily due to the high computational cost of frequency res...
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Article
Open AccessAssociation between different MAP levels and 30-day mortality in sepsis patients: a propensity-score-matched, retrospective cohort study
Sepsis is a life-threatening organ dysfunction caused by the infection-related host response disorder. Adequate mean arterial pressure is an important prerequisite of tissue and organ perfusion, which runs thr...
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Article
A preliminary study on the acoustic properties of seafloor sediment in the southern U-boundary of the South China Sea
The acoustic properties of seafloor sediment are essential parameters in the exploration of marine resources, ocean scientific research and ocean engineering. Seafloor sediment samples were collected at the so...
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Article
Open AccessRegeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan
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Article
Open AccessResearch on outpatient capacity planning combining lean thinking and integer linear programming
The size and cost of outpatient capacity directly affect the operational efficiency of a whole hospital. Many scholars have faced the study of outpatient capacity planning from an operations management perspec...
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Article
A high-dimensional optimization method combining projection correlation-based Kriging and multimodal parallel computing
In surrogate-based optimization (SBO), the recognized issues associated with the high-dimensional surrogate models focus on the prohibitive computational costs and the low model accuracy. However, there is a l...
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Article
Intelligent optimization of stiffener unit cell via variational autoencoder-based feature extraction
Grid-stiffened structures are widely used in industrial equipment, where the layout of stiffener unit cells is critical in the structural performance. However, owing to the lack of design techniques, existing ...
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Article
Concurrent numerical implementation of vibration correlation technique for fast buckling load prediction of cylindrical shells under combined loading conditions
As a non-destructive buckling experimental technique, the vibration correlation technique (VCT) is extensively applied in buckling load prediction of columns, plates and shells under axial compression load. Fo...
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Article
Open AccessThe effect of a chrysanthemum water extract in protecting the retina of mice from light damage
Oxidative stress can induce age-related diseases. Age-related retinal diseases, such as age-related macular degeneration (AMD), are difficult to cure owing to their complicated mechanisms. Although anti-neovas...
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Article
Open AccessIGF2BP1-regulated expression of ERRα is involved in metabolic reprogramming of chemotherapy resistant osteosarcoma cells
Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while acquired drug resistance seriously attenuates its treatment efficiency. The present study aimed to investigate the potential ro...
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Article
Open AccessChronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar
Spinal cord injury (SCI) is a severe damage usually leading to limb dysesthesia, motor dysfunction, and other physiological disability. We have previously shown that NT3-chitosan could trigger an acute SCI rep...
