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Article

Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing

CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur...

Juan-Juan Zhao, **n-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin… in BMC Genomics (2024)