38 Result(s)
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Chapter and Conference Paper
Phylogenesis of the Vertebrate Immune System
Our current knowledge of the phylogenesis of immunity is exclusively based on studies of comparative immunity. We know, for example, that some functional components of the vertebrate immune system such as allo...
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Chapter and Conference Paper
Segregation of DQ and DR: “Exceptions to the Rule”
The strong associations of DQw1 with DR1, 2, w6, and w10, of DQw2 with DR3 and 7, and of DQw3 with DR4 and 5 have been defined in studies with cells of Caucasoid origin. The use of monoclonal antibodies and ca...
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Chapter and Conference Paper
Antigen Report: HLA-Bw67
During the Sixth and Seventh Workshop, new HLA-B specificities (SN-2, BF, Te90) intermediate between B16 and Bw22 were described [1, 2]. During the Eighth Workshop, these specificities were coded as 8w57: the ...
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Chapter and Conference Paper
Antigen Report: HLA-Cw3
Cw3 was first described by means of two sera, UPS from Copenhagen and Sa-50 from Gothenburg [9]. This antigen was confirmed as belonging to the third HLA series at the 1975 Workshop [8], where it was called Cw...
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Chapter and Conference Paper
Antigen Report: HLA-Aw43
In 1972, the occurrence of apparent triplets associated with HLA-A10 and A29 in the Khoisan populations of Namibia was reported [1]. In 1975 [6], an HLA-A10/A29 allele was defined in terms of the Fifth Interna...
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Chapter and Conference Paper
HLA Polymorphisms in Southern African Populations
HLA is a powerful tool, as it is the most polymorphic genetic system known in man, determined by heredity in a known way, unchangeable during the life of an individual and observable by relatively simple blood...
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Chapter and Conference Paper
RFLP Standardization Report for DR Alpha/KpnI
Four bands were identified by the RFLP analysis in the DR alpha/KPN system as shown in Table 1 and in Figure 1. RFLP patterns of the core cell lines are shown in Table 2.
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Chapter and Conference Paper
RFLP Standardization Report for DP Alpha/KpnI
Six bands were identified by the RFLP analysis in the DP alpha/KPN system as shown in Table 1 and in Figure 1. RFLP patterns of the core cell lines are shown in Table 2.
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Chapter and Conference Paper
DR3 (DRw17, DRw18): 2-D Gel Patterns
Six DR3 cell lines were included in the Workshop study (Table 1). Two-dimensional (2-D) gel patterns for both α chains and β chains were obtained using the panel of core monomorphic and selected polymorphic mo...
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Chapter and Conference Paper
Unusual DR-DQ Haplotypes
The linkage disequilibrium existing between HLA-DR and DQ antigens is so strong that associations that do not follow the pattern appear as exceptions. In Caucasoids, the associations are well known: DQw1 is li...
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Chapter and Conference Paper
Evolutions of the Immune System
Determining the relative importance of the elements of the immune sytem is a major task to which comparative studies may help first in pointing to key elements and second in suggesting their phylogenetic origi...
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Chapter and Conference Paper
Antigen Society #26 Report (DR3, DR7, DQw2): Part 1
There were 1,019 cells analyzed in the Antigen Society (795 Caucasians, 202 Negroes, 22 Orientals); 1,011 were tested both on Core serology and Antigen Society reagents. The total number of sera and monoclonal...
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Chapter and Conference Paper
DQw2: 2-D Gel Patterns
The pH gradient used in this study was not optimal for the two-dimensional (2-D) gel analysis of the DQβ chains from DQw2 cell lines. Therefore, only the most acidic, highly glycosylated form of this extremely...
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Chapter and Conference Paper
DQw4 (Wa): 2-D Gel Patterns
DQw4 (Wa) is a class II specificity defined in the 10th Workshop as a fourth allele at the DQ locus. It is revealed serologically with the mouse monoclonal antibody Hu-46, which reacts with some DR4 and DRw8 h...
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Chapter and Conference Paper
Antigen Society #2 Report (A25, A26, AW34, AW43 and AW66)
The HLA antigens A25, A26, AW34, AW43, and AW66 form a strongly cross-reacting group as most sera to these antigens react with two or more of these specificities. Monospecific sera against some of these specif...
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Chapter and Conference Paper
Antigen Society #12 Report (Bw54, Bw55, Bw56 and Bw42)
The antigen Bw54 was officially designated as a split of Bw22 at the Seventh International Histocompatibility Workshop. This antigen was primarily defined in the Japanese population by several laboratories ind...
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Chapter and Conference Paper
Antigen Society #18 Report (Cw4 and Cw6)
HLA-Cw4 (formerly T4, RH315) and HLA-Cw6 (formerly T7) obtained the formal HLA designation after the Sixth and Seventh International Histocompatibility Workshops respectively (1,2). Since then, it has been obs...
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Chapter and Conference Paper
T Cell Differentiation in Lower Vertebrates
With all the recent advances in the study of T cell differentiation in mice, it is reasonable to question whether anything can be fetched from the examination of this problem in lower vertebrates. One obvious ...
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Chapter and Conference Paper
Southern Blot Analysis of Rheumatoid Arthritis
The methods and materials used in the Southern blot analysis of rheumatoid arthritis (RA) study were identical to the conditions used in the core and family study sections of the Tenth Workshop (10WS) Southern...
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Chapter and Conference Paper
DRw6 (DRw13, DRw14): 2-D Gel Patterns
DRw6 (DRw13,DRw14) haplotypes were previously considered to be the most enigmatic group of HLA class II specificities. This was largely due to the lack of monospecific anti-DRw6 alloantisera. Through the combi...
