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  1. No Access

    Chapter

    Role of Mechanical Factors in the Aetiology, Pathogenesis and Progression of Osteoarthritis

    Motion and mechanical stimulation play a critical role in the development of the skeleton and normal joints [1, 2]. Movement, loading and intermittent mechanical strain are also crucial for the maintenance of ...

    G. Nuki in Osteoarthritis (1999)

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    Chapter

    Non-Steroidal Anti-Inflammatory Drugs and Infertility

    Non-steroidal anti-inflammatory drugs (NSAIDs) are widely self-administered for the relief of musculoskeletal pain and commonly prescribed for women of child-bearing age with inflammatory arthritis. Although t...

    G. Nuki, G. Smith, C. Hall, R. Roberts in Side Effects of Anti-Inflammatory Drugs IV (1997)

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    Chapter

    Congenital Chloride Losing Enteropathy Associated with Tophaceous Gouty Arthritis

    Congenital chloride losing enteropathy (familial chloride diarrhoea, congenital chloridorrhea)(1) is a recessively inherited disorder which results from a defect in chloride/bicarbonate exchange in the ileum. ...

    G. Nuki, M. L. Watson, B. C. Williams… in Purine and Pyrimidine Metabolism in Man VII (1991)

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    Chapter and Conference Paper

    Crystal-Associated Inflammation: Some Mechanisms of Cellular Activation

    Acute inflammation in association with crystals of monosodium urate is thought to be mediated by the presence of polymorphonuclear leucocytes (PMN) both in acute gouty arthritis and in experimentally induced c...

    G. Nuki in Urate Deposition in Man and its Clinical Consequences (1991)

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    Chapter

    Azapropazone in gout and hyperuricaemia

    After 20 years of clinical use as a non-steroidal anti-inflammatory drug (NSAID) azapropazone is now well established as both a useful agent for treating attacks of acute gouty arthritis and as single agent in...

    G. Nuki, F. Grinlinton, J. Palit, R. Wallace in Azapropazone (1989)

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    Chapter

    The Macrophage—Origins, Functions and Role in the Rheumatic Diseases

    Metchnikoff1 recognized the importance of the macrophage in host defence and in mounting inflammatory responses in the nineteenth century; indeed it formed the cornerstone for his cellular theory of immunity. A v...

    N. Hurst, G. Nuki in Immunological Aspects of Rheumatology (1981)

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    Chapter

    Purine and Pyrimidine Nucleotide Concentrations in Cells with Decreased Hypoxanthine-Guanine-Phosphoribosyltransferase (HGPRT) Activity

    Severe and partial deficiency of the enzyme Hypoxanthineguanine-phosphoribosyl-transferase (HGPRT) (EC.2.4.2.8.) is associated with accelerated rates of purine biosynthesis de novo, both in vivo (1,2,3) and in cu...

    G. Nuki, K. Astrin, D. Brenton, M. Cruikshank, J. Lever… in Purine Metabolism in Man—II (1977)