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Nanoparticles for Tissue Engineering: Type, Properties, and Characterization
The multidisciplinary area of tissue engineering unifies various fields such as medical biology, engineering, and material science that focus on develo** biological alternatives to increase the functions of ...
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Application of Nanoparticles in Soft Tissue Engineering
Tissue engineering is an interdisciplinary approach that integrates several fields of study such as biology, biochemistry, chemistry, nanotechnology, engineering, and material science. Three components are com...
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Strategies to Improve Delivery of Bioactive Agents
The delivery of bioactive agents/drugs in disease therapy and its improper disposal is one of the major causes of the constant rise in pollution levels. The majority of these factors depend upon alternative ap...
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Challenges and Future Prospect of Nanoparticles in Tissue Engineering
Tissue engineering (TE) is a process where the damaged tissues and organs are recovered in a natural process using the patient’s physiological system. This involves fully repairing or regenerating damaged orga...
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Nanoparticles and Bioceramics Used in Hard Tissue Engineering
Tissue engineering is an interdisciplinary field. Despite the name, most tissue engineering does not involve traditional engineering. Tissue engineering is about restoring tissue damaged by trauma or disease t...
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3D and 4D Nanoprinting for Tissue Regeneration
In recent years, to deliver an effective transplantation process and develop better disease models, considerable efforts are devoted to advancing innovative techniques and strategies for tissue regeneration. N...
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Chapter
Nanotechnology and Its Applications in Molecular Detection
Nanotechnology deals with the manipulation of single atoms and molecules to build devices of nano- or microscale to use for various purposes in several fields. Through its unique properties, it has unraveled a...
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Chapter
Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and diseased alveoli. As the first lung-on-a-chip products have...
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Chapter
Understanding and Engineering the Pulmonary Vasculature
Blood vessels play essential roles in regulating embryonic organogenesis and adult tissue homeostasis. The inner lining of blood vessels is covered by vascular endothelial cells, which exhibit tissue-specific ...
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Clinical Translation of Engineered Pulmonary Vascular Models
Diseases in pulmonary vasculature remain a major cause of morbidity and mortality worldwide. Numerous pre-clinical animal models were developed to understand lung vasculature during diseases and development. H...
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Chapter
Current and Future Engineering Strategies for ECMO Therapy
Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung is compromised. Venous blood is pumped through an oxygenati...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential treatments for lung diseases. A wide variety of rodent and human...
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Correction to: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
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Chapter
Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system development, multipotent mesenchymal and epithelial progenitors d...
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Chapter
Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways
The large airways are a critical component of the respiratory tree serving both an immunoprotective role and a physiological role for ventilation. The physiological role of the large airways is to move a large...
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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs. Specialized cells in the lung mesenchyme produce the extracellula...
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Chapter
Assessment of Collagen in Translational Models of Lung Research
The extracellular matrix (ECM) plays an important role in lung health and disease. Collagen is the main component of the lung ECM, widely used for the establishment of in vitro and organotypic models of lung d...
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An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases
Traditionally, animal models have been used for recapitulating human physiology and for studying the pathological basis of many diseases affecting humankind. Indeed, over the centuries, animal models helped ad...
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Extracorporeal Membrane Oxygenation: Set-up, Indications, and Complications
Extracorporeal membrane oxygenation (ECMO) occupies an increasingly important position in the clinic for the management of cardiac and/or pulmonary failure. As a rescue therapy, ECMO can support patients follo...
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Chapter
An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA) sequencing, induced pluripotent stem cell (iPSC) reprogramming...