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Chapter
Origin of new genes: evidence from experimental and computational analyses
Exon shuffling is an essential molecular mechanism for the formation of new genes. Many cases of exon shuffling have been reported in vertebrate genes. These discoveries revealed the importance of exon shuffli...
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Chapter
Inhibition of Cysteine and Serine Proteinases by the Cowpox Virus Serpin CRMA
Interleukin lß converting enzyme (ICE) is the founding member of a family of cysteine proteinases active in the metabolism of intracellular proteins [1]. Other members of this family include Ich-1, CPP32, Ced-...
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Chapter
Correlation of Acute Prostacyclin Response in Primary (Unexplained) Pulmonary Hypertension with Efficacy of Treatment with Calcium Channel Blockers and Survival
Unexplained, or primary, pulmonary hypertension, is usually a rapidly fatal disease, in which the use of vasodilator therapy is controversial (14, 22, 25). While some authors have proposed that there may be a ...
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Chapter
Application of Electrochemical and UV/Visible Detection to the LC Separation and Determination of Methylene Blue and Its Demethylated Metabolites from Milk
A study was initiated to find a suitable HPLC detection scheme for the determination of methylene blue(MB) in several types of complex animal tissues, milk and milk product matrices. In addition to methylene b...
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Chapter
The Application of Matrix Solid Phase Dispersion (MSPD) to the Extraction and Subsequent Analysis of Drug Residues in Animal Tissues
The contamination of our environment and of our food supply with industrial, agricultural and pharmaceutical agents possessing toxicologic and/or pharmacologic character are major man-made problems that must b...
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Chapter
Protein C: Gene Structure and Protein Synthesis
Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by spe...
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Chapter
Biosynthesis and Endocytosis of Yolk Proteins in the Mosquito
The maturation of insect eggs requires the fat body production of large amounts of a protein, vitellogenin (Vg), that is secreted into the hemolymph, selectively accumulated by the oocytes and stored in yolk b...