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Chapter
Inhibition of Cysteine and Serine Proteinases by the Cowpox Virus Serpin CRMA
Interleukin lß converting enzyme (ICE) is the founding member of a family of cysteine proteinases active in the metabolism of intracellular proteins [1]. Other members of this family include Ich-1, CPP32, Ced-...
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Chapter
Stimulation of Human Anti-Viral CD8+ Cytolytic T Lymphocytes by Dendritic Cells
Antigen-specific CD8+ cytolytic T lymphocytes [CTLs] are considered to be important mediators of resistance in several human infections [e.g. influenza (1), HIV-1 (2), cytomegalovirus (3), malaria (4)] and mal...
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Chapter
Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics
Current insulin formulations do not mimic the normal glucose-induced release of insulin by the pancreas in a physiological manner.1 One limitation is the delayed absorption of hexameric insulin from the subcutane...
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Chapter
Application of Electrochemical and UV/Visible Detection to the LC Separation and Determination of Methylene Blue and Its Demethylated Metabolites from Milk
A study was initiated to find a suitable HPLC detection scheme for the determination of methylene blue(MB) in several types of complex animal tissues, milk and milk product matrices. In addition to methylene b...
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Chapter
The Application of Matrix Solid Phase Dispersion (MSPD) to the Extraction and Subsequent Analysis of Drug Residues in Animal Tissues
The contamination of our environment and of our food supply with industrial, agricultural and pharmaceutical agents possessing toxicologic and/or pharmacologic character are major man-made problems that must b...
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Chapter
Protein C: Gene Structure and Protein Synthesis
Protein C is a vitamin K-dependent plasma glycoprotein that, after activation by thrombin-thrombomodulin upon the endothelial cell surface, serves as a feedback down-regulator of the coagulation cascade by spe...
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Chapter
Absorption and Optical Rotation Spectra of Biological Membranes
The combination of ultraviolet absorption and circular dichroism (CD) spectroscopies provides a sensitive technique for following protein conformation and conformational changes in solution. It is reasonable t...